Histamine and the striatum.
Histamine and the striatum.
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DOI：
10.1016/j.neuropharm.2015.08.013
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发表时间：
2016-07
影响因子：
4.7
通讯作者：
Ellender TJ
中科院分区：
文献类型：
--
作者：
Bolam JP;Ellender TJ
神经调节剂组胺在清醒期间在整个大脑中释放。结合组胺受体的丰富表达，这表明潜在的广泛的组胺能神经回路活动的控制。然而，组胺对许多这些电路的影响是未知的。在这篇综述中，我们将讨论最近的证据组胺能调制的基底神经节电路，特别是其主要输入核纹状体。此外，我们将讨论最近的研究结果，组胺能功能障碍的几个基底神经节疾病，包括帕金森氏病和最突出的，在抽动秽语综合征，这导致了复苏的兴趣，这种神经调质。结合起来，这些最近的观察结果不仅表明组胺在调节基底神经节活动和行为中的中心作用，而且还作为治疗基底神经节疾病的可能靶点。这篇文章是题为“组胺受体”的特刊的一部分。
The neuromodulator histamine is released throughout the brain during periods of wakefulness. Combined with an abundant expression of histamine receptors, this suggests potential widespread histaminergic control of neural circuit activity. However, the effect of histamine on many of these circuits is unknown. In this review we will discuss recent evidence for histaminergic modulation of the basal ganglia circuitry, and specifically its main input nucleus; the striatum. Furthermore, we will discuss recent findings of histaminergic dysfunction in several basal ganglia disorders, including in Parkinson's disease and most prominently, in Tourette's syndrome, which has led to a resurgence of interest in this neuromodulator. Combined, these recent observations not only suggest a central role for histamine in modulating basal ganglia activity and behaviour, but also as a possible target in treating basal ganglia disorders. This article is part of the Special Issue entitled ‘Histamine Receptors’.