Midbrain volume increase in patients with panic disorder
Midbrain volume increase in patients with panic disorder
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DOI：
10.1111/j.1440-1819.2011.02219.x
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发表时间：
2011-01-01
影响因子：
11.9
通讯作者：
Hirayasu, Yoshio
中科院分区：
文献类型：
--
作者：
Fujiwara, Akiko;Yoshida, Takeshi;Hirayasu, Yoshio
目的：虽然最近的研究表明，异常的大脑皮层，边缘结构，和脑干区域的惊恐障碍（PD），在何种程度上中脑与PD的病理生理学尚不清楚。本研究的目的是探讨结构异常的中脑使用磁共振成像，并确定是否有一个临床相关性中脑体积和临床测量的患者PD.Methods：38例PD患者（PD组）和38名健康对照组（HC组）参加了这项研究。采用高空间分辨率磁共振成像手动追踪方法测量中脑。惊恐障碍严重程度量表和功能的整体评估被用来检查体积异常和临床症状和功能在PD group.Results之间的相关性：相对中脑体积在PD组大于HC组。背侧中脑的相对体积在PD组中较大，而腹侧中脑的体积没有。我们发现相对背侧中脑体积与惊恐障碍严重程度量表总评分之间存在显著正相关，而相对背侧中脑体积与PD组功能总体评估评分之间存在显著负相关。
Aim: Although recent studies suggest abnormalities of the cerebral cortex, limbic structures, and brain stem regions in panic disorder (PD), the extent to which the midbrain is associated with PD pathophysiology is unclear. The aim of this study was to investigate structural abnormalities of the midbrain using magnetic resonance imaging and to determine if there is a clinical correlation between midbrain volume and clinical measurements in patients with PD.Methods: Thirty-eight patients with PD (PD group) and 38 healthy controls (HC group) participated in this study. The midbrain was measured with a manual tracing method with high spatial resolution magnetic resonance imaging. The Panic Disorder Severity Scale and Global Assessment of Functioning were used to examine the correlation between volume abnormality and clinical symptoms and functioning in the PD group.Results: Relative midbrain volume was larger in the PD group than in the HC group. The relative volume of the dorsal midbrain was larger in the PD group, while the volume of the ventral midbrain was not. We found a significant positive correlation between relative dorsal midbrain volume and total Panic Disorder Severity Scale score, and a significant negative correlation between relative dorsal midbrain volume and Global Assessment of Functioning score in the PD group.