Unified Protocol for Cobalt-Catalyzed Oxidative Assembly of Two Aryl Metal Reagents Using Oxygen as an Oxidant
Unified Protocol for Cobalt-Catalyzed Oxidative Assembly of Two Aryl Metal Reagents Using Oxygen as an Oxidant
复制标题
使用氧气作为氧化剂钴催化氧化组装两种芳基金属试剂的统一方案
DOI：
10.1021/acs.joc.5b01787
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发表时间：
2015-10-16
影响因子：
3.6
通讯作者：
Duan, Xin-Fang
中科院分区：
文献类型：
--
作者：
Liao, Lian-Yan;Liu, Kun-Ming;Duan, Xin-Fang
首次报道了钴催化的两种芳基金属试剂的氧化偶联反应。等量的两种芳基格氏试剂或锂试剂，在通过等量的简单ClTi-（OEt）（3）介导之后，在1摩尔%的CoCl 2/10摩尔%的DMPU的催化下使用氧气容易地组装。各种芳基金属试剂之间的交叉偶联反应，特别是两个结构相似的芳基格氏试剂之间的交叉偶联反应，顺利和选择性地进行，因此，提供了一个高度通用和有效的方法来构建联芳基化合物。
The first cobalt-catalyzed oxidative cross-coupling reaction of two aryl metal reagents is described. An equivalent amount of two aryl Grignard or lithium reagents, after mediation by an equivalent amount of simple ClTi-(OEt)(3), was facilely assembled under the catalysis of 1 mol % of CoCl2/10 mol % of DMPU using oxygen. The cross-couplings between various aryl metal reagents, especially between two structurally similar aryl Grignard reagents, proceeded smoothly and selectively and, thus, provided a highly general and efficient method for the construction of biaryl compounds.