Robust Estimation of Respiratory Variability Uncovers Correlates of Limbic Brain Activity and Transcutaneous Cervical Vagus Nerve Stimulation in the Context of Traumatic Stress.
Robust Estimation of Respiratory Variability Uncovers Correlates of Limbic Brain Activity and Transcutaneous Cervical Vagus Nerve Stimulation in the Context of Traumatic Stress.
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DOI：
10.1109/tbme.2021.3108135
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Inan OT
中科院分区：
文献类型：
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作者：
Gazi AH;Wittbrodt MT;Harrison AB;Sundararaj S;Gurel NZ;Nye JA;Shah AJ;Vaccarino V;Bremner JD;Inan OT
呼吸模式的变化是由于潜在的神经呼吸耦合引起的对痛苦的特征性反应。然而，迄今为止，还没有工作量化的呼吸模式变异性（RPV）的背景下，创伤性应激反应，并研究其功能的神经相关性-这项分析旨在解决这一差距。50名具有先前创伤经历的人类受试者（24名患有创伤后应激障碍（PTSD））完成了涉及个性化创伤脚本和主动/假（双盲）经皮颈部迷走神经刺激（tcVNS）的约3小时方案。高分辨率正电子发射断层扫描功能神经影像，心电图（ECG），呼吸努力（RSP）的数据收集过程中的协议。用ECG衍生的呼吸补充RSP信号以进行质量评估和定时提取，定量和分析RPV指标。具体而言，相关性分析进行了选择的边缘区域的神经活动，并积极和假tcVNS的反应进行了比较。非PTSD患者呼吸频率的单滞后无标度自相关与左侧杏仁核活性呈负相关，与右侧前额叶皮层（rmPFC）活性呈正相关; PTSD患者呼吸频率的单滞后无标度自相关与左侧和右侧岛叶活性呈负相关，与右侧rmPFC活性呈正相关。呼气时间的单滞后无标度自相关性在非PTSD的主动刺激后更大。定量RPV对于评估创伤引起的神经功能变化和tcVNS对呼吸生理的影响具有明显的重要性。这是RPV与创伤应激和tcVNS诱导的神经呼吸反应相关性的首次证明。本文阐述的开源处理流水线唯一地包括RSP和ECG导出的呼吸信号，用于质量评估、定时估计和RPV提取。
Variations in respiration patterns are a characteristic response to distress due to underlying neurorespiratory couplings. Yet, no work to date has quantified respiration pattern variability (RPV) in the context of traumatic stress and studied its functional neural correlates – this analysis aims to address this gap. Fifty human subjects with prior traumatic experiences (24 with posttraumatic stress disorder (PTSD)) completed a ~3-hr protocol involving personalized traumatic scripts and active/sham (double-blind) transcutaneous cervical vagus nerve stimulation (tcVNS). High-resolution positron emission tomography functional neuroimages, electrocardiogram (ECG), and respiratory effort (RSP) data were collected during the protocol. Supplementing the RSP signal with ECG-derived respiration for quality assessment and timing extraction, RPV metrics were quantified and analyzed. Specifically, correlation analyses were performed using neuroactivity in selected limbic regions, and responses to active and sham tcVNS were compared. The single-lag unscaled autocorrelation of respiration rate correlated negatively with left amygdala activity and positively with right rostromedial prefrontal cortex (rmPFC) activity for non-PTSD; it also correlated negatively with left and right insulae activity and positively with right rmPFC activity for PTSD. The single-lag unscaled autocorrelation of expiration time was greater following active stimulation for non-PTSD. Quantifying RPV is of demonstrable importance to assessing trauma-induced changes in neural function and tcVNS effects on respiratory physiology. This is the first demonstration of RPV’s pertinence to traumatic stress- and tcVNS-induced neurorespiratory responses. The open-source processing pipeline elucidated herein uniquely includes both RSP and ECG-derived respiration signals for quality assessment, timing estimation, and RPV extraction.