lola has the properties of a master regulator of axon-target interaction for SNb motor axons of Drosophila
lola has the properties of a master regulator of axon-target interaction for SNb motor axons of Drosophila
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DOI：
10.1006/dbio.1999.9399
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发表时间：
1999-09-15
影响因子：
2.7
通讯作者：
Giniger, E
中科院分区：
文献类型：
--
作者：
Madden, K;Crowner, D;Giniger, E
轴突的正确寻路和目标识别需要大量指导因子的精确编排表达：指导性和许可性，阳性和阴性，分泌和膜结合。我们在这里表明，转录因子LOLA是必需的寻路和靶向的SNB运动神经在果蝇。我们还表明，洛拉是SNB发展的剂量依赖性调节：通过改变一个洛拉亚型的表达，我们可以逐步滴定SNB运动轴突与其靶肌肉的相互作用的程度，从根本没有相互作用，通过野生型图案，明显hypernervedication。我们从LOLA表达改变中观察到的表型表明，这种蛋白质可能有助于协调SNb发育所需基因的协调表达。(C)北京：科学出版社.
The proper pathfinding and target recognition of an axon requires the precisely choreographed expression of a multitude of guidance factors: instructive and permissive, positive and negative, and secreted and membrane bound. We show here that the transcription factor LOLA is required for pathfinding and targeting of the SNb motor nerve in Drosophila. We also show that lola is a dose-dependent regulator of SNb development: by varying the expression of one lola isoform we can progressively titrate the extent of interaction of SNb motor axons with their target muscles, from no interaction at all, through wild-type patterning, to apparent hyperinnervation. The phenotypes we observe from altered expression of LOLA suggest that this protein may help orchestrate the coordinated expression of the genes required for faithful SNb development. (C) 1999 Academic Press.