Chromosomal assignment of 14 genomic probes for highly polymorphic loci.
Chromosomal assignment of 14 genomic probes for highly polymorphic loci.
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高度多态性位点的 14 个基因组探针的染色体分配。
DOI：
10.1159/000132728
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Donis-Keller,H
中科院分区：
文献类型：
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作者：
Cohen-Haguenauer,O;NguyenVanCong;Knowlton,RG;deTand,MF;Jegou,C;Gross,MS;Brown,VA;Frézal,J;Donis-Keller,H
Over 500 probes revealing restriction fragment length polymorphisms (RFLPs) have been isolated by Schumm et al. (1988). We describe here the chromosomal assignment of 14 of the most highly polymorphic markers in that set of probes, with polymorphism information content values of up to 0.98. The probes were mapped using a panel of human × rodent somatic cell hybrids and were found to be distributed among nine different autosomes. Chromosome localization of such highly polymorphic markers has been an important step in the construction of the human genetic map, as a large number of RFLP probes has now been localized by genetic linkage studies to these loci.
