EMETIC EFFECTS OF ANTICANCER DRUGS AND INVOLVEMENT OF VISCERAL AFFERENT-FIBERS AND 5-HT3 RECEPTORS IN DOGS
EMETIC EFFECTS OF ANTICANCER DRUGS AND INVOLVEMENT OF VISCERAL AFFERENT-FIBERS AND 5-HT3 RECEPTORS IN DOGS
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DOI：
10.1016/0014-2999(93)90392-u
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发表时间：
1993-12-07
影响因子：
5
通讯作者：
SATO, S
中科院分区：
文献类型：
--
作者：
FUKUI, H;YAMAMOTO, M;SATO, S
本文观察了环磷酰胺、氮芥、放线菌素D、5-氟尿嘧啶和L-门冬酰胺酶等5种抗癌药物的催吐作用，以及切断双侧迷走神经、切断双侧内脏大神经或5-HT_3受体拮抗剂对上述药物催吐作用的影响。环磷酰胺（20 mg/kg，静脉注射），氮芥-N-氧化物（5 mg/kg，i. v.）和放线菌素D（50 μ g/kg，i. v.）引起狗呕吐，潜伏期很长。5-氟尿嘧啶（5 mg/kg，静脉注射）和L-天冬酰胺酶（2000 K.U./ kg，i.v.）未能引起呕吐。双侧腹部迷走神经切断和双侧内脏大神经切断可完全抑制前三种抗癌药物引起的呕吐。此外，静脉内给予ICS 205930（2 x 0.1 mg/kg）（一种5-HT 3受体拮抗剂）可完全抑制呕吐。上述结果提示，5-HT_3受体介导环磷酰胺、氮芥-N-氧化物和放线菌素D引起的呕吐。
The emetic effects of five anticancer drugs, cyclophosphamide, nitrogen mustard-N-oxide, actinomycin D, 5-fluorouracil and L-asparaginase, and the effects of bilateral abdominal vagotomy and bilateral greater splanchnic nerve section or a 5-HT3 receptor antagonist on the emesis induced by these drugs were investigated in dogs. Cyclophosphamide (20 mg/kg, i.v.), nitrogen mustard-N-oxide (5 mg/kg, i.v.) and actinomycin D (50 mug/kg, i.v.) caused vomiting in dogs with a long latency period. 5-Fluorouracil (5 mg/kg, i.v.) and L-asparaginase (2000 K.U./kg, i.v.) failed to induce vomiting. Bilateral abdominal vagotomy and bilateral greater splanchnic nerve section completely inhibited the vomiting induced by the former three anticancer drugs. Furthermore, the vomiting was inhibited completely by intravenous administration of ICS205930 (2 x 0.1 mg/kg), a 5-HT3 receptor antagonist. These results suggest that activation of visceral afferents through 5-HT3 receptors mediates the vomiting induced by cyclophosphamide, nitrogen mustard-N-oxide and actinomycin D.