The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours
The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours
复制标题
DOI：
10.1177/0748730408316166
复制
发表时间：
2008-06-01
影响因子：
3.5
通讯作者：
Shea, Steven A.
中科院分区：
文献类型：
--
作者：
Hu, Kun;Scheer, Frank A. J. L.;Shea, Steven A.
哺乳动物的心跳波动显示出一个强大的时间结构，其特征在于尺度不变/分形图案。这些尺度不变的模式可能赋予生理优势，因为它们随着心血管疾病而变化，这些变化与生存率降低有关。物理系统的模型意味着要产生尺度不变的模式，在不同时间尺度上影响系统的因素必须通过反馈相互作用网络耦合。一个类似的心脏控制网络被假设为负责心跳动力学中的尺度不变模式，虽然还没有确定的基本网络组件。这里显示，尺度不变的心脏控制发生在从几分钟到近似24小时的时间尺度上，并且损伤哺乳动物昼夜节律起搏器（视交叉上核; SCN）完全消除了时间尺度>近似4小时的尺度不变模式。在时间尺度上
Heartbeat fluctuations in mammals display a robust temporal structure characterized by scale-invariant/fractal patterns. These scale-invariant patterns likely confer physiological advantage because they change with cardiovascular disease and these changes are associated with reduced survival. Models of physical systems imply that to produce scale-invariant patterns, factors influencing the system at different time scales must be coupled via a network of feedback interactions. A similar cardiac control network is hypothesized to be responsible for the scale-invariant pattern in heartbeat dynamics, although the essential network components have not been determined. Here is shown that scale-invariant cardiac control occurs across time scales from minutes to similar to 24 h, and that lesioning the mammalian circadian pacemaker (suprachiasmatic nucleus; SCN) completely abolishes the scale-invariant pattern at time scales >similar to 4 h. At time scales