Recent advances in alcoholic liver disease - III. Role of the innate immune response in alcoholic hepatitis
Recent advances in alcoholic liver disease - III. Role of the innate immune response in alcoholic hepatitis
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DOI：
10.1152/ajpgi.00094.2004
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发表时间：
2004-08-01
影响因子：
4.5
通讯作者：
Wheeler, MD
中科院分区：
文献类型：
--
作者：
Hines, IN;Wheeler, MD
乙醇消耗是已知的，导致严重的急性肝损伤，导致肝纤维化和最终肝硬化时，消耗慢性。乙醇对肝脏产生损害作用的机制尚不清楚;然而，最近的科学研究已经开始描绘酒精性肝病的最早期事件。从这些研究中，很明显，先天免疫系统的组成部分，特别是库普弗细胞，在这一过程中发挥了重要作用。越来越清楚的是，包括T细胞在内的免疫系统的其他部分也可能负责介导慢性酒精消耗对肝脏的破坏性影响。这篇综述将强调最近的实验表明先天免疫反应在酒精诱导的肝炎和随后的器官损伤的启动和进展中的作用。
Ethanol consumption is known to cause significant acute liver damage resulting in hepatic fibrosis and eventual cirrhosis when consumed chronically. The mechanism(s) by which ethanol exerts its damaging effects on the liver are not well understood; however, recent scientific investigation has begun to delineate the earliest events in alcoholic liver disease. From these studies, it is apparent that components of the innate immune system and, in particular, Kupffer cells, play a significant role in this process. It is also becoming clear that other parts of the immune system including T cells may also be responsible for mediating the devastating effects of chronic alcohol consumption on the liver. This review will highlight recent experiments demonstrating a role for the innate immune response in the initiation and progression of alcohol-induced liver hepatitis and subsequent organ damage.