UNEXPLAINED SPONTANEOUS REGRESSION AND ALPHA-INTERFERON AS TREATMENT FOR METASTATIC RENAL-CARCINOMA
UNEXPLAINED SPONTANEOUS REGRESSION AND ALPHA-INTERFERON AS TREATMENT FOR METASTATIC RENAL-CARCINOMA
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DOI：
10.1111/j.1464-410x.1989.tb05147.x
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发表时间：
1989-02-01
期刊：
影响因子：
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通讯作者：
BOTTOMLEY, JM
中科院分区：
文献类型：
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作者：
OLIVER, RTD;NETHERSELL, ABW;BOTTOMLEY, JM
一系列的73例可测量的转移性疾病转诊到三级转诊中心考虑实验性治疗方案的患者进入监测方案，以确定自发消退的发生率。最初，如果转移显示二维测量结果增加> 25%，则患者退出研究，但随着置信度的增加，患者仅在症状进展后才进入治疗方案。我们观察到3例完全和2例部分原因不明的自发性消退，另外4例患者的疾病稳定时间超过12个月。一组21例进展患者随后接受α-干扰素（Wellferon）治疗，作为多中心研究的一部分，其中包括另外61例病例; 12例应答（3例监测复发患者和9例其他患者）。仅肺转移患者的缓解率最高（10/17例，相比之下，在监测的38例此类患者中观察到5例原因不明的缓解）。这些结果证实α-干扰素对转移性肾癌有活性，并且这种反应不能完全用自发消退来解释。
A series of 73 patients with measurable metastatic disease referred to a tertiary referral centre for consideration for an experimental treatment protocol were entered into a surveillance protocol in order to establish the incidence of spontaneous regression. Initially, patients were taken off the study if metastases showed > 25% increase in products of bidimensional measurement but with increasing confidence patients went into therapy protocols only following the development of symptomatic progression. We observed 3 complete and 2 partial unexplained spontaneous regressions and a further 4 patients had prolonged stable disease for more than 12 months. A group of 21 patients on progression subsequently received treatment with alpha-interferon (Wellferon) as part of a multicentre study which included an additional 61 cases; 12 responded (3 surveillance relapse patients and 9 others). Patients with lung metastases only had the highest response rate (10/17 compared with 5 unexplained responses seen in 38 such patients on surveillance). These results confirm that alpha-interferon is active against metastatic renal carcinoma and that the responses are not totally explicable by spontaneous regression.