The Alabama Preterm Birth study: polymorphonuclear and mononuclear cell placental infiltrations, other markers of inflammation, and outcomes in 23- to 32-week preterm newborn infants
The Alabama Preterm Birth study: polymorphonuclear and mononuclear cell placental infiltrations, other markers of inflammation, and outcomes in 23- to 32-week preterm newborn infants
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DOI：
10.1016/j.ajog.2006.06.083
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发表时间：
2006-09-01
影响因子：
9.8
通讯作者：
Hauth, John C.
中科院分区：
文献类型：
--
作者：
Andrews, William W.;Goldenberg, Robert L.;Hauth, John C.
目的：本研究的目的是为了更好地了解胎盘中性粒细胞和单核细胞浸润与细菌培养、炎症标志物和早产结局的关系。研究设计：这是一项前瞻性研究，研究对象为446名胎龄32周的单胎婴儿。结果与胎盘和脐带培养、脐带白细胞介素6水平和新生儿结局进行了比较。结果：多形核而非单核细胞浸润在早期妊娠和黑人妇女中更为常见(56.0%vs39.3%；P<；0.01)。中性粒细胞浸润与自然早产相关(73.9%比8.0%；P<；0.0001)，与先兆子痫无关(9.9%比34%；P<；0.0001)。培养阳性、白细胞介素6水平高和临床绒毛膜羊膜炎的妇女都比没有这些情况的妇女有显著更多的中性粒细胞浸润(所有概率值，
Objective: The purpose of this study was to better understand the relationship between placental polymorphonuclear and mononuclear cell infiltrations with bacterial cultures, markers of inflammation, and preterm outcomes.Study design: This was a prospective study in 446 women who were delivered of a singleton infant at < 32 weeks of gestational age. Five placental sites were categorized as having polymorphonuclear or mononuclear infiltrations.Results were compared with placental and cord cultures, umbilical cord interleukin-6 levels, and neonatal outcomes. Results: Polymorphonuclear, but not mononuclear, cell infiltrations were more common at the earliest gestational ages and in black women (56.0% vs 39.3%; P < .01). Polymorphonuclear infiltration was associated with spontaneous preterm birth (73.9% vs 8.0%; P < .0001), but not with preeclampsia (9.9% vs 34%; P < .0001). Women with positive cultures, high interleukin-6 levels, and clinical chorioamnionitis all had significantly more polymorphonuclear infiltrations than did women without those conditions (all probability values,