Pathways of translation: deep brain stimulation.

Pathways of translation: deep brain stimulation.
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DOI:
10.1111/cts.12055
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发表时间:
2013-12
期刊:
Clinical and translational science
影响因子:
--
通讯作者:
Lee KH
Lee KH
中科院分区:
其他
文献类型:
--
作者:
Gionfriddo MR;Greenberg AJ;Wahegaonkar AL;Lee KH

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大脑电刺激已有2000年的历史。深部脑刺激(DBS)是神经刺激的一种形式,是一种功能性神经外科方法,其中高频电流刺激目标脑结构以获得治疗效果。它是治疗某些神经病理运动障碍的有效方法,也是治疗精神疾病和癫痫的一种新兴疗法。它的转化之旅并没有遵循典型的从实验室到病床的路径,而是相反的过程。从古代和中世纪的民间疗法到公认的医疗实践的转变始于17世纪对电的独立发现,并受到20世纪技术进步的推动。在本文中,我们回顾了这段历程,并讨论了扩展其应用并继续改善结果的探索如何将DBS从病床边带回临床试验台上。
Electrical stimulation of the brain has a 2000 year history. Deep brain stimulation (DBS), one form of neurostimulation, is a functional neurosurgical approach in which a high frequency electric current stimulates targeted brain structures for therapeutic benefit. It is an effective treatment for certain neuropathologic movement disorders and an emerging therapy for psychiatric conditions and epilepsy. Its translational journey did not follow the typical bench-to-bedside path, but rather reversed the process. The shift from ancient and medieval folkloric remedy to accepted medical practice began with independent discoveries about electricity during the 17th century and was fostered by technological advances of the 20th. In this article we review that journey and discuss how the quest to expand its applications and continue to improve outcomes is taking DBS from the bedside back to the bench.
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