The relationship between plasma levels of leptin and androgen in healthy and preeclamptic pregnant women
The relationship between plasma levels of leptin and androgen in healthy and preeclamptic pregnant women
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DOI：
10.1111/j.0001-6349.2004.00276.x
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发表时间：
2004-05-01
影响因子：
4.3
通讯作者：
Atamer, A
中科院分区：
文献类型：
--
作者：
Atamer, Y;Erden, AC;Atamer, A
为了阐明瘦素和雄激素在先兆子痫发病机制中的作用，我们想评估母体瘦素在重度和轻度先兆子痫妇女中的作用以及性类固醇激素对瘦素产生的影响。研究组包括40名健康孕妇（HPW）、55名重度子痫前期（SPE）孕妇和41名轻度子痫前期（MPE）孕妇。三组之间在年龄、胎龄和体重指数（BMI）方面无显著差异。测定血浆瘦素、总睾酮（T）、雌二醇（EA）、硫酸脱氢表雄酮（DHEAS）和雄烯二酮（A）水平。采用SPSS for Windows统计软件进行单因素方差分析（ANOVA）和Tukey honesty significant difference（HSD）检验，计算Pearson相关系数。SPE组和MPE组血浆瘦素水平显著升高（p < 0.001），而血浆T水平仅在SPE组显著升高（p < 0.001）。三组间血浆DHEAS水平无显著性差异（P> 0.05）。MPE组血浆A水平明显降低（p < 0.05）。MPE组与SPE组血浆E-2水平无显著性差异（p> 0.05）。MPE组血浆瘦素水平与E-2水平呈显著正相关（r = 0.41，P < 0.001）。我们的结论是，血浆瘦素和睾酮水平的升高可能有助于参与先兆子痫的发病机制的内皮功能障碍，雌二醇可能会导致血浆瘦素水平的增加。
Background To clarify the role of leptin and androgens in the pathogenesis of preeclampsia, we wanted to assess role of maternal leptin in women with severe and mild preeclampsia and the effects of sex steroid hormones on leptin production.Methods. The groups consisted of 40 healthy pregnant women (HPW) as well as 55 pregnant women with severe preeclampsia (SPE) and 41 pregnant women with mild preeclampsia (MPE). No significant differences were observed between the three groups regarding age, gestational age and body mass index (BMI). Plasma leptin, total testosterone (T), estradiol (EA dehydroepiandrosterone sulfate (DHEAS) and androstenedione (A) levels were measured. Statistical analysis was achieved with one-way analysis of variance (ANOVA) followed by post hoc multiple comparisons with the Tukey honestly significant difference (HSD) test by using SPSS for Windows statistical computer program, and the Pearson's coefficient of correlation was calculated.Results. The plasma level of leptin was significantly increased in the SPE and MPE groups (p < 0.001), whereas the plasma level of T was significantly increased only in the SPE group (p < 0.001). However, there was no significant difference in plasma levels of DHEAS among the three groups (p < 0.05). The plasma level of A was significantly decreased in the MPE group (p < 0.05). There was no significant difference in the plasma level of E-2 in the MPE and SPE groups (p < 0.05). There was a significant positive correlation between the plasma levels of leptin and E-2 in the MPE group (r = 0.41, P < 0.001).Conclusion. We concluded that the elevated plasma levels of leptin and testosterone could contribute to the endothelial dysfunction involved in the pathogenesis of preeclampsia, and that estradiol might lead to an increase in the plasma levels of leptin.