Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process.
Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process.
复制标题
DOI：
10.3390/ijms22073709
复制
发表时间：
2021-04-02
影响因子：
5.6
通讯作者：
Nakahata Y
中科院分区：
文献类型：
--
作者：
Khaidizar FD;Bessho Y;Nakahata Y
衰老是一种由复杂的分子和生化变化引起的现象。烟酰胺腺嘌呤二核苷酸（NAD+）是一种引起强烈研究兴趣的代谢物，在模型动物和人类的各种组织中，其细胞水平已被证明随着年龄的增长而下降。NAD+前体，烟酰胺单核苷酸（NMN）和烟酰胺核苷（NR），通过NAD+回收途径补充NAD+的产生，已被证明可以减缓小鼠的衰老过程。因此，NAD+是一种关键的代谢物，现在被认为可以减轻衰老动物中与年龄相关的组织功能下降和预防与年龄相关的疾病。在人体临床试验中，老年人服用NAD+前体被用于解决与年龄相关的全身性生理衰退。在哺乳动物NAD+生物合成途径中，NAD+打捞途径在大多数组织中都是主导途径，而NAMPT是该途径的限速酶。然而，到目前为止，仅开发出几种可以增加NAD+的NAMPT活化剂。在这篇综述中，我们将重点介绍NAD+的重要性以及NAMPT激活剂在促进连续衰老中的可能应用。
Aging is a phenomenon underlined by complex molecular and biochemical changes that occur over time. One of the metabolites that is gaining strong research interest is nicotinamide adenine dinucleotide, NAD+, whose cellular level has been shown to decrease with age in various tissues of model animals and humans. Administration of NAD+ precursors, nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), to supplement NAD+ production through the NAD+ salvage pathway has been demonstrated to slow down aging processes in mice. Therefore, NAD+ is a critical metabolite now understood to mitigate age-related tissue function decline and prevent age-related diseases in aging animals. In human clinical trials, administration of NAD+ precursors to the elderly is being used to address systemic age-associated physiological decline. Among NAD+ biosynthesis pathways in mammals, the NAD+ salvage pathway is the dominant pathway in most of tissues, and NAMPT is the rate limiting enzyme of this pathway. However, only a few activators of NAMPT, which are supposed to increase NAD+, have been developed so far. In this review, we will focus on the importance of NAD+ and the possible application of an activator of NAMPT to promote successive aging.
登录
查看更多内容
血浆NAD（+）代谢组在“正常”衰老中失调。
影响因子：
2.6
作者：
Clement J;Wong M;Poljak A;Sachdev P;Braidy N
通讯作者：
Braidy N
影响因子：
2.7
作者：
Han, Xue;Bao, Xiaogang;Shi, Qiaojuan
通讯作者：
Shi, Qiaojuan
影响因子：
4.8
作者：
Boshoff, Helena I. M.;Xu, Xia;Barry, Clifton E., III
通讯作者：
Barry, Clifton E., III
影响因子：
7.8
作者：
Borradaile, Nica M.;Pickering, J. Geoffrey
通讯作者：
Pickering, J. Geoffrey
影响因子：
6.3
作者：
de Guia, Roldan M.;Hassing, Anna S.;Treebak, Jonas T.
通讯作者：
Treebak, Jonas T.