Alzheimer's disease in the parents of women with trisomic spontaneous abortions.
Alzheimer's disease in the parents of women with trisomic spontaneous abortions.
复制标题
三体自然流产妇女的父母患有阿尔茨海默病。
DOI：
10.1097/00001756-200003200-00028
复制
发表时间：
2000
期刊：
影响因子：
1.7
通讯作者：
Warburton,D
中科院分区：
文献类型：
--
作者：
Kline,J;Kinney,A;Levin,B;Mayeux,R;Schupf,N;Warburton,D
We tested whether familial aggregation of Down syndrome and Alzheimer's disease (AD) is present for trisomies of other autosomes. We compared rates of Alzheimer-like dementia in the parents of women with trisomic pregnancy losses (n= 109) with those in parents of women with chromosomally normal losses (n= 151) and births (n= 216). Relative risks of Alzheimer-like dementia in parents of women with trisomic losses were 1.2 (95% Cl 0.6, 2.2) and 0.9 (95% Cl 0.5, 1.5) in comparison to parents of women with chromosomally normal losses and births, respectively. Associations were similar among women whose index pregnancy occurred before age 35 or later. Our data do not support an association between the occurrence of AD and trisomy of all autosomal chromosomes. They raise the possibility that familial aggregation with AD is specific to trisomy 21.
