Expression profiling to predict outcome in breast cancer: the influence of sample selection.

Expression profiling to predict outcome in breast cancer: the influence of sample selection.
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表达分析以预测乳腺癌的预后:样本选择的影响。

DOI:
10.1186/bcr548
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发表时间:
2003
影响因子:
7.4
通讯作者:
Meltzer, PS
Meltzer, PS
中科院分区:
医学1区
文献类型:
--
作者:
Gruvberger, SK;Ringnér, M;Edén, P;Borg, Å;Fernö, M;Peterson, C;Meltzer, PS

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利用DNA微阵列进行肿瘤基因表达谱分析是预测癌症患者预后和治疗反应的一种很有前途的方法。最近有报道称,散发性乳腺癌的表达谱可以比目前可用的临床和组织病理学预后因素更好地预测疾病的复发。在观察到预测结果的基因和预测雌激素受体-α状态的基因之间的重叠后,我们在一个独立的数据集中检查了它们的预测能力。我们的结论是,对于雌激素受体-α阳性和雌激素受体-α阴性的肿瘤,分别定义预后表达谱可能是重要的。
Gene expression profiling of tumors using DNA microarrays is a promising method for predicting prognosis and treatment response in cancer patients. It was recently reported that expression profiles of sporadic breast cancers could be used to predict disease recurrence better than currently available clinical and histopathological prognostic factors. Having observed an overlap in those data between the genes that predict outcome and those that predict estrogen receptor-α status, we examined their predictive power in an independent data set. We conclude that it may be important to define prognostic expression profiles separately for estrogen receptor-α-positive and estrogen receptor-α-negative tumors.
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