Association between loss of bone mass due to short sleep and leptin-sympathetic nervous system activity
Association between loss of bone mass due to short sleep and leptin-sympathetic nervous system activity
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DOI：
10.1016/j.archger.2017.02.005
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发表时间：
2017-05-01
影响因子：
4
通讯作者：
Watanabe, Yoshiyuki
中科院分区：
文献类型：
--
作者：
Kuriyama, Nagato;Inaba, Masaaki;Watanabe, Yoshiyuki
研究背景：睡眠是骨代谢的重要因素，交感神经系统活动调节骨代谢。在这项研究中，我们评估了睡眠、交感神经系统活动和骨量之间的关系。方法：研究对象221人，其中男性108人，女性113人，平均年龄55.1±7.0岁，分为每天睡眠不足6小时组（短睡眠组[SS]）和睡眠6小时及以上组（正常睡眠组[NS]）。通过心率变异性分析，比较各组在生活方式、皮质骨厚度、松质骨密度、骨代谢指标、血瘦素水平和交感神经系统活动方面的差异。结果：两组小鼠皮质骨厚度、血TRACP-5b、瘦素水平均有显著差异。L/H比值（交感神经系统活动指数）SS组高于NS组。骨皮质厚度与L/H比和瘦素水平呈显著负相关，L/H比与瘦素水平呈显著正相关。结论：短睡眠与中年人骨吸收促进和交感神经系统亢进导致皮质骨厚度下降有关。瘦素水平与皮质骨厚度密切相关，提示皮质骨量可能通过与瘦素交感神经系统的相互作用来调节。(C) 2017 Elsevier B.V.版权所有
Background: Sleep has been reported to be an important factor in bone metabolism, and sympathetic nervous system activity has been reported to regulate bone metabolism. In this study, we evaluated the association between sleep, sympathetic nervous system activity, and bone mass.Methods: The study subjects were 221 individuals (108 males; 113 females; mean age: 55.1 +/- 7.0 years) divided into two groups: those who slept for less than 6 h a day (short sleep [SS] group), and those who slept 6 h or longer (normal sleep [NS] group). The groups were compared with regard to lifestyle, cortical bone thickness, cancellous bone density, bone metabolism markers, blood leptin levels, and sympathetic nervous system activity as evaluated by heart rate variability analysis.Results: Significant differences were observed between the two groups in cortical bone thickness, blood TRACP-5b, and leptin levels. The L/H ratio (an index of sympathetic nervous system activity) was higher in the SS group than in the NS group. Significant negative correlations were observed between cortical bone thickness and both the L/H ratio and leptin levels, and a significant positive correlation was observed between the L/H ratio and leptin levels.Conclusions: Short sleep was associated with a decline in cortical bone thickness due to the promotion of bone resorption and sympathetic nervous system hyperactivity in the middle-aged group. Leptin levels and cortical bone thickness were found to be closely related, suggesting that cortical bone mass may be regulated via interaction with the leptin-sympathetic nervous system. (C) 2017 Elsevier B.V. All rights reserved.