T-cell populations in liver and renal transplant recipients with infectious esophagitis.
T-cell populations in liver and renal transplant recipients with infectious esophagitis.
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患有传染性食管炎的肝肾移植受者中的 T 细胞群。
DOI：
10.1007/bf01536160
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发表时间：
1989
影响因子：
3.1
通讯作者：
VanThiel,DH
中科院分区：
文献类型：
--
作者：
Brouillette,DE;Alexander,J;Yoo,YK;Chien,MC;Tarter,RE;Gavaler,J;VanThiel,DH
接受肝和肾移植的个体易受胃肠道感染，特别是食道感染。最常见的致病因子是念珠菌和单纯疱疹病毒（HSV），巨细胞病毒（CMV），曲霉菌和其他被认为是不常见的病原体，即使在这个独特的人群。T细胞群的改变与健康同性恋者和获得性免疫缺陷综合征（艾滋病）患者的巨细胞病毒结肠炎有关。同样，感染Epstein-Ban病毒的个体也改变了T细胞群。这些感染是否改变了受感染个体的T细胞群，或者T细胞亚群的异常首先发生并增加了易感人群感染的可能性，目前尚不清楚。在这项研究中，对19例患者肝移植前、47例患者肝移植后和21例患者肾移植后的外周血T细胞群进行了比较。那些有任何食管疾病相关症状的个体接受了上消化道内镜检查联合粘膜活检、刷检和培养，并被细分为有和没有感染性食管炎的个体。发现CMV食管炎与T细胞辅助/抑制（H/S）比值的算术降低有关，主要是由于抑制细胞数量的增加。这种TH/S比值和循环抑制细胞数量的减少在HSV或念珠菌引起的食管炎中没有发现，并且与血清环孢素水平或泼尼松剂量无关。因此，由于CMV食管炎患者循环抑制细胞数量增加而导致的H/S比值降低可能是由于CMV感染本身的存在，而不是导致个体发生CMV感染的因素。
Individuals undergoing hepatic and renal transplants are susceptible to infections of the gastrointestinal tract, particularly the esophagus. The most common responsible agents are Candida and herpes simplex virus (HSV) with cytomegalovirus (CMV), Aspergillus, and other agents being regarded as unusual pathogens even in this unique population. Altered T-cell populations have been associated with CMV colitis in healthy homosexuals and in individuals with the acquired immunodeficiency syndrome (AIDS). Similarly, individuals with Epstein-Ban virus infections have altered T-cell populations. Whether these infections alter T-cell populations in infected individuals or the abnormalities in T-cell subpopulations occur first and enhance the likelihood of an infection in susceptible populations is as yet unknown. In this study peripheral blood T-cell populations in individuals before (19 patients) and after (47 patients) liver transplantation and after receiving a renal allograft (21 patients) were compared. Those individual having any symptoms related to esophageal disease underwent upper gastrointestinal endoscopy combined with mucosal biopsies, brushings, and cultures and were subdivided into those with and without infectious esophagitis. CMV esophagitis was found to be associated with an arithmetically decreased T-cell helper/supressor H/S) ratio principally due to an increase in the suppressor cell number. Such a reduction in the TH/Sratio and in the number of circulating suppressor cells was not found in esophagitis due to either HSV or Candida and was unrelated to the serum cyclosporine level or prednisone dosage prescribed. Therefore the reduced H/S ratio due to an increase in the circulating suppressor cell number in patients with CMV esophagitis is probably due to the presence of the CMV infection per se rather than a factor predisposing the individual for a CMV infection.
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DOI：
10.1083/jcb.85.2.361
发表时间：
1980-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Fowler V;Taylor DL
通讯作者：
Taylor DL
膜骨架对红细胞变形性、膜材料特性和形状的影响。
影响因子：
3.6
作者：
Mohandas,N;Chasis,JA;Shohet,SB
通讯作者：
Shohet,SB
遗传性椭圆红细胞增多症患者亚群中血影蛋白的分子缺陷。
DOI：
10.1172/jci111376
发表时间：
1984
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Lawler,J;Liu,SC;Palek,J;Prchal,J
通讯作者：
Prchal,J
影响因子：
158.5
作者：
AGRE, P;ORRINGER, EP;BENNETT, V
通讯作者：
BENNETT, V
糖连接蛋白 (PAS 2)，人红细胞细胞骨架的膜附着位点。
DOI：
--
发表时间：
1981
期刊：
Progress in clinical and biological research
影响因子：
--
作者：
Mueller Tj;M. Morrison
通讯作者：
M. Morrison