Unusual sites of extraskeletal metastases of Ewing sarcoma after allogeneic hematopoietic stem cell transplantation.
Unusual sites of extraskeletal metastases of Ewing sarcoma after allogeneic hematopoietic stem cell transplantation.
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DOI：
10.1097/mph.0b013e31819146e5
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发表时间：
2009-02
影响因子：
1.2
通讯作者：
Fry, Terry J.
中科院分区：
文献类型：
--
作者：
Capitini, Christian M.;Derdak, Joanne;Hughes, Marybeth S.;Love, Cynthia P.;Baird, Kristin;Mackall, Crystal L.;Fry, Terry J.
异基因干细胞移植（SCT）治疗实体瘤仍在研究中。我们报告一例转移性、难治性尤文肉瘤患者在接受非清髓性外周血SCT治疗后病情稳定。值得注意的是，患者发生了两个不寻常部位的转移性疾病-脑和小肠。同种异体SCT环境可以改变典型的转移模式，并且可以代表操纵和增强抗肿瘤免疫应答的理想平台。需要进一步的临床试验来评估同种异体SCT对这种疾病的作用。
Allogeneic stem cell transplantation (SCT) for solid tumors remains under investigation. We report a case of extended disease stability after a non-myeloablative peripheral blood SCT for metastatic, refractory Ewing sarcoma. Of note, the patient developed metastatic disease to two unusual sites – the brain and small intestine. The allogeneic SCT environment may alter typical metastatic patterns, and may represent an ideal platform to manipulate and enhance the anti-tumor immune response. Further clinical trials are needed to evaluate the role for allogeneic SCT for this disease.