Cobalt from metal-on-metal hip replacements may be the clinically relevant active agent responsible for periprosthetic tissue reactions
Cobalt from metal-on-metal hip replacements may be the clinically relevant active agent responsible for periprosthetic tissue reactions
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DOI：
10.1016/j.actbio.2012.05.003
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发表时间：
2012-10-01
影响因子：
9.7
通讯作者：
Mosselmans, J. Fred W.
中科院分区：
文献类型：
--
作者：
Hart, Alister J.;Quinn, Paul D.;Mosselmans, J. Fred W.
一些类型的金属对金属(MOM)髋关节置换术的失败率高得令人无法接受，例如Ultima TPS MoM髋关节，5年时失败率为13.8%。这归因于钴(Co)和铬(Cr)从轴承表面和模块接头释放出来后的炎症反应。有体外证据表明，钴在炎症过程中比铬更重要，但还没有关于种植体衍生金属分析的人体组织研究报告。(C)2012 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Some types of metal-on-metal (MOM) hip replacements have unacceptably high rates of failure, such as the Ultima TPS MOM hip, with 13.8% failure at 5 years. This has been attributed to an inflammatory reaction following the release of cobalt (Co) and chromium (Cr) from the bearing surfaces and modular junctions. There is in vitro evidence that Co is more important than Cr in the inflammatory process, but there are no reported human tissue studies of the analysis of implant-derived metals. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.