Regulation of Autophagy by mTOR Signaling Pathway
Regulation of Autophagy by mTOR Signaling Pathway
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DOI：
10.1007/978-981-15-0602-4_3
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Zhang, Hongbing
中科院分区：
文献类型：
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作者：
Wang, Ying;Zhang, Hongbing
自噬在维持细胞稳态中发挥着至关重要的作用，与人类多种疾病的发生密切相关。众所周知，自噬是响应各种环境应激（例如营养缺乏、生长因子缺乏和缺氧）而发生的。诱导自噬消除了这些压力造成的损伤，并在压力缓解后恢复到正常水平。为了理解各种应激条件下自噬的诱导以及自噬对细胞生命过程的影响，有必要了解自噬是如何调节的。许多研究表明多种信号转导途径参与自噬的调控。在这些途径中，一些途径汇聚于雷帕霉素（TOR）的靶点，雷帕霉素是一种高度保守的激酶，对于自噬调节非常重要。本综述将重点讨论TOR信号通路在自噬调控中的作用。
Autophagy plays a crucial role in maintaining cellular homeostasis, and is closely related to the occurrence of variety of human diseases. It is known that autophagy occurs in response to various environmental stresses such as nutrient deficiency, growth factor deficiency, and hypoxia. Induced autophagy eliminates the damage caused by these stresses and returns to normal levels when the stresses are relieved. To comprehend the induction of autophagy under various stress conditions and the effects of autophagy on the life processes of cells, it is necessary to understand how autophagy is regulated. Many studies have shown that a number of signal transduction pathways are involved in the regulation of autophagy. Among these pathways, some pathways converge at the target of rapamycin (TOR), a highly conserved kinase important for autophagy regulation. This review will focus on the role of TOR signaling pathway in the regulation of autophagy.