Cardanol as a replacement for cholesterol into the lipid bilayer of POPC liposomes
Cardanol as a replacement for cholesterol into the lipid bilayer of POPC liposomes
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DOI：
10.1016/j.colsurfb.2004.09.007
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发表时间：
2005-01-15
影响因子：
5.8
通讯作者：
Velluto, D
中科院分区：
文献类型：
--
作者：
De Maria, P;Filippone, P;Velluto, D
通过水合1-棕榈酰-2-油基磷脂酰胆碱（POPC）膜和随后挤出所获得的脂质体悬浮液来制备大的单层脂质体。胆固醇和腰果酚的包含带来脂质体膜的稳定，如通过它们释放截留的5（6）-羧基荧光素的速率所确定的。脂质体分解由非离子表面活性剂（Triton X-100）促进，并且动力学测量通过在水中在25 ℃下的荧光法进行。还进行了pant POPC脂质体在存在和不存在两种客体的情况下的形态学分析。所获得的结果表明使用腰果酚（一种容易获得的天然产物）作为胆固醇的替代物作为稳定药物靶向中的脂质体的新的可能性。(C)2004 Elsevier B. V.保留所有权利。
Large unilamellar liposomes were prepared by hydration of 1-palmitoyl-2-oleylphosphatydilcholine (POPC) films and subsequent extrusion of the obtained liposomal suspension. Inclusion of cholesterol and cardanol brings about a stabilization of the membranes of the liposomes, as determined by their rates of release of entrapped 5(6)-carboxyfluorescein. The liposome breakdown was promoted by a non-ionic surfactant (Triton X-100) and the kinetic measurements were carried out by fluorimetry in water at 25degreesC. Morphological analyses of pant POPC liposomes in the presence and in the absence of both guests were also performed. The results obtained suggest the use of cardanol (an easy available natural product) as a replacement for cholesterol as a new possibility for stabilizing liposomes in drug targetting. (C) 2004 Elsevier B.V. All rights reserved.