A STRENGTHENING PROGRAM FOR WEAK ASSOCIATIONS
A STRENGTHENING PROGRAM FOR WEAK ASSOCIATIONS
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DOI：
10.1093/ije/17.4.955
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发表时间：
1988-12-01
影响因子：
7.7
通讯作者：
POOLE, C
中科院分区：
文献类型：
--
作者：
ROTHMAN, KJ;POOLE, C
因果关系的强度取决于同一疾病的其他组成原因的相对流行率。弱关联有时可以通过限制对低风险人群的关注来加强。这种技术可能会导致更少的受试者进行研究，但仍然可以提供更多的信息，以评估因果关系。加强关联的第二种方法是减少非差异错误分类，这种错误分类往往会淡化关联。增加对暴露、疾病以及因果作用与疾病发作之间的时间的测量的特异性，应产生更强的关联，更容易解释，更能描述潜在的因果机制。
The strength of a causal association depends on the relative prevalence of other component causes for the same disease. Weak associations may sometimes be strengthened by restricting attention to people at low risk. This technique may lead to fewer subjects to study, but nevertheless may provide more information by which to evaluate a causal relation. A second method for strengthening associations is to reduce non-differential misclassification, which tends to dilute associations. Increasing the specificity of measurement for exposure, disease, and the timing between causal action and disease onset should produce stronger associations that are easier to interpret and more descriptive of the underlying causal mechanism.