Systemic lupus erythematosus. VI. Analysis of the interrelationship with pregnancy.
Systemic lupus erythematosus. VI. Analysis of the interrelationship with pregnancy.
复制标题
系统性红斑狼疮。
作者：
H. Nossent;T. Swaak
在19例患者的39次妊娠中检查了系统性红斑狼疮（SLE）对妊娠的影响，反之亦然，并将结果与其他18例患者的24次妊娠进行了比较。胎儿丢失或早产率没有差异，尽管更多的婴儿出生时低出生体重后，SLE被诊断;有一个优势，在两组中的女婴。SLE期间妊娠伴有疾病加重的患者高达74%。这些加重主要涉及肌肉骨骼（41%）和血液学异常（36%），而器官受累发生在所有加重的13%中。根据狼疮活动性标准计数（LACC），活动期和静止期SLE患者的妊娠结局无差异。母亲体内SSA抗体的存在与先天性心脏传导阻滞的发生有关;抗磷脂抗体与胎儿丢失之间没有发现关联。
The influence of systemic lupus erythematosus (SLE) on pregnancy and vice versa was examined during 39 pregnancies in 19 patients, and outcome was compared with 24 pregnancies in 18 other patients before SLE was established. No difference in fetal loss or premature birth rate was found, although more babies were born with low birth weight after SLE was diagnosed; there was a preponderance of female babies in both groups. Pregnancy during SLE was accompanied by disease exacerbations in up to 74% of all patients. These exacerbations concerned mostly musculoskeletal (41%) and hematological abnormalities (36%), while organ involvement occurred in 13% of all exacerbations. No differences in pregnancy outcome during SLE were found between patients with active or quiescent disease, as established by the lupus activity criteria count (LACC). The presence of antibodies to SSA in the mother was associated with the occurrence of congenital heart block; no association was found between antiphospholipid antibodies and fetal loss.