Animal models for the molecular and mechanistic study of lymphatic biology and disease
Animal models for the molecular and mechanistic study of lymphatic biology and disease
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DOI：
10.1196/annals.1413.005
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Rockson, Stanley G.
中科院分区：
文献类型：
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作者：
Shin, William S.;Rockson, Stanley G.
淋巴系统研究的动物模型系统的发展导致了关于淋巴发育机制和与淋巴功能障碍相关的疾病的信息爆炸。动物研究已经导致了一个新的胚胎淋巴管发育的分子模型，并提供了深入了解遗传性和获得性淋巴功能不全的病理生理学。然而，淋巴系统对人类疾病的重要性已经变得明显，超出其在水肿中的作用，延伸到许多其他不同的病理过程，包括非常值得注意的炎症和肿瘤淋巴管生成。在这里，我们已经进行了系统的审查模型，因为它们涉及的发展，成熟，遗传学，遗传性和获得性疾病的分子和功能表征，以及淋巴系统的肿瘤影响。将这些进展转化为与淋巴功能障碍相关的人类疾病的治疗方法，将需要通过模拟人类疾病的强大动物疾病模型继续研究淋巴系统。
The development of animal model systems for the study of the lymphatic system has resulted in an explosion of information regarding the mechanisms governing lymphatic development and the diseases associated with lymphatic dysfunction. Animal studies have led to a new molecular model of embryonic lymphatic vascular development, and have provided insight into the pathophysiology of both inherited and acquired lymphatic insufficiency. It has become apparent, however, that the importance of the lymphatic system to human disease extends, beyond its role in lymphedema, to many other diverse pathologic processes, including, very notably, inflammation and tumor lymphangiogenesis. Here, we have undertaken a systematic review of the models as they relate to molecular and functional characterization of the development, maturation, genetics, heritable and acquired diseases, and neoplastic implications of the lymphatic system. The translation of these advances into therapies for human diseases associated with lymphatic dysfunction will require the continued study of the lymphatic system through robust animal disease models that simulate their human counterparts.