Hyperintense Dentate Nuclei on T1-Weighted MRI: Relation to Repeat Gadolinium Administration.
Hyperintense Dentate Nuclei on T1-Weighted MRI: Relation to Repeat Gadolinium Administration.
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DOI：
10.3174/ajnr.a4378
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Yousem DM
中科院分区：
文献类型：
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作者：
Adin ME;Kleinberg L;Vaidya D;Zan E;Mirbagheri S;Yousem DM
T1 加权 MR 图像上齿状核的高信号表现与各种临床状况有关，但病因仍不确定。我们的目的是研究暴露于辐射的患者 T1 加权 MR 图像上齿状核高信号外观与因素之间可能的关联，这些因素包括但不限于对比增强 MR 图像的累积数量、钆给药量、电离辐射剂量和患者人口统计数据。两名读者对 1995 年至 2010 年间在约翰·霍普金斯医疗机构连续接受脑部照射治疗的 706 名患者的医疗记录进行了盲审。一百八十四名受试者被纳入齿状核分析。在静脉注射钆后累计接受 2677 次 MR 成像研究的 184 名受试者中，103 名患者在对比前 T1 加权 MR 图像上出现高信号齿状核。在正常齿状核组中进行的钆增强 MR 成像研究的平均数量显着低于高信号齿状核组。平均随访时间为 62.5 个月。在高信号组和正常齿状核组之间，在暴露辐射剂量、血清肌酐和钙/磷酸盐水平、患者人口统计、化疗史和扫描仪强度方面没有观察到显着差异。齿状核高信号患者的相应 CT 扫描未发现齿状核异常 (n = 44)。 53 名健康志愿者未发现齿状核异常。钆增强研究的重复表现可能导致造影前 T1 加权 MR 图像上齿状核长期出现高信号。
A hyperintense appearance of the dentate nucleus on T1-weighted MR images has been related to various clinical conditions, but the etiology remains indeterminate. We aimed to investigate the possible associations between a hyperintense appearance of the dentate nucleus on T1-weighted MR images in patients exposed to radiation and factors including, but not limited to, the cumulative number of contrast-enhanced MR images, amount of gadolinium administration, dosage of ionizing radiation, and patient demographics. The medical records of 706 consecutive patients who were treated with brain irradiation at The Johns Hopkins Medical Institutions between 1995 and 2010 were blindly reviewed by 2 readers. One hundred eighty-four subjects were included for dentate nuclei analysis. Among the 184 subjects who cumulatively underwent 2677 MR imaging studies following intravenous gadolinium administration, 103 patients had hyperintense dentate nuclei on precontrast T1-weighted MR images. The average number of gadolinium-enhanced MR imaging studies performed in the group with normal dentate nuclei was significantly lower than that of the group with hyperintense dentate nuclei. The average follow-up time was 62.5 months. No significant difference was observed between hyperintense and normal dentate nuclei groups in terms of exposed radiation dose, serum creatinine and calcium/phosphate levels, patient demographics, history of chemotherapy, and strength of the scanner. No dentate nuclei abnormalities were found on the corresponding CT scans of patients with hyperintense dentate nuclei (n = 44). No dentate nuclei abnormalities were found in 53 healthy volunteers. Repeat performance of gadolinium-enhanced studies likely contributes to a long-standing hyperintense appearance of dentate nuclei on precontrast T1-weighted-MR images.