Behaviour of untreated proliferative sickle retinopathy.
Behaviour of untreated proliferative sickle retinopathy.
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未经治疗的增殖性镰状视网膜病变的行为。
DOI：
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发表时间：
1980
影响因子：
4.1
通讯作者：
G. R. Serjeant
中科院分区：
文献类型：
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作者：
P. Condon;G. R. Serjeant
本文报告了313例镰状细胞病患者眼部病变的发展，随访1--8年。在567只眼睛中，68只（12%）在初始检查时存在镰状视网膜病变（PSR），并在研究期间在另外46只（8%）眼睛中发展。33只（49%）最初患有PSR的眼睛在初始检查时出现自发消退（自体梗死），并在研究期间在另外45只（39%）眼睛中发展。PSR的发展在镰状细胞血红蛋白C（SC）疾病中更常见，而自体梗死似乎更常见于纯合子镰状细胞（SS）疾病。这两个过程是微妙的平衡，一些PSR病变持续不到一年前发生自体梗死。虽然自体梗死的高患病率减少了PSR的临床后遗症，但14/119（12%）只眼发生了与PSR相关的失明。自体梗死闭合PSR病变的供血血管比光凝更优雅，且没有与光凝相关的并发症。更深入地了解参与PSR进展和消退的因素与确定光凝在这种情况下的作用有关。
The development of ocular lesions in 313 patients with sickle cell disease followed up for periods of 1--8 years is described. Proliferative sickle retinopathy (PSR) was present on initial examination in 68 (12%) of 567 eyes and developed in a further 46 (8%) eyes during the study period. Spontaneous regression (autoinfarction) was present on initial examination in 33 (49%) eyes with PSR initially and developed in a further 45 (39%) eyes during the study. Development of PSR was more common in sickle cell-haemoglobin C (SC) disease, and autoinfarction appeared to occur more commonly in homozygous sickle cell (SS) disease. The two processes were delicately balanced, and some PSR lesions lasted less than a year before undergoing autoinfarction. Although the high prevalence of autoinfarction diminishes the clinical sequelae of PSR, blindness related to PSR occurred in 14/119 (12%) eyes. Autoinfarction closes the feeding vessels of PSR lesions more elegantly than, and without the complications associated with, photocoagulation. A greater understanding of factors involved in the progression and regression of PSR is relevant to defining the role of photocoagulation in this condition.