Significance of Lymphangiogenesis in Primary Tumor and Draining Lymph Nodes During Lymphatic Metastasis of Pancreatic Head Cancer
Significance of Lymphangiogenesis in Primary Tumor and Draining Lymph Nodes During Lymphatic Metastasis of Pancreatic Head Cancer
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DOI：
10.1002/jso.21744
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发表时间：
2010-12-01
影响因子：
2.5
通讯作者：
Natsugoe, Shoji
中科院分区：
文献类型：
--
作者：
Kurahara, Hiroshi;Takao, Sonshin;Natsugoe, Shoji
背景和目的：本研究的目的是探讨淋巴管生成在胰腺癌原发肿瘤和胰头癌淋巴转移时引流淋巴结中的意义。为了评估淋巴管生成，我们使用D2-40抗体测量了原发肿瘤和引流淋巴结中的淋巴管密度(LVD)。结果：原发灶低密度组的淋巴结转移率明显高于低密度组(P=0.0006)，术后生存率明显低于低密度组(P=0.0066)。结内LVDS随结内转移灶大小的增大而增大。有转移者无转移结节的左心室射血分数也显著高于无转移者(P<；0.0001)。有腹主动脉旁转移的患者胰周结节的LVDS明显高于无腹主动脉旁转移的患者(P<；0.0001)。结论：原发肿瘤和引流淋巴结中淋巴管的生成是肿瘤细胞通过淋巴系统有效扩散所必需的。因此，抑制淋巴管生成可以限制肿瘤细胞的淋巴扩散。J·奥科尔外科医生。2010；102：809-815。(C)2010年Wiley-Liss公司
Background and Objectives: The aim of this study was to investigate the significance of lymphangiogenesis in primary pancreatic tumors and in draining lymph nodes during lymphatic metastasis of pancreatic head cancers.Methods: Specimens were obtained from 70 patients. To evaluate lymphangiogenesis, we measured lymphatic vessel density (LVD) using D2-40 antibody in the primary tumors and in the draining lymph nodes. AE1/AE3 antibody was used to detect tiny, histologically negative metastases in lymph nodes.Results: Patients with high LVD of primary tumors had significantly higher incidence of node metastasis (P = 0.0006) and lower postoperative survival rate (P = 0.0066) than those with low LVD. Intranodal LVDs increased with increasing size of the intranodal metastases. The LVDs of non-metastatic nodes in patients with node metastasis were also significantly higher than those of non-metastatic nodes in patients without node metastasis (P < 0.0001). The LVDs of peripancreatic nodes in patients with paraaortic node metastases were significantly higher than those in patients without paraaortic metastasis (P < 0.0001).Conclusions: Lymphangiogenesis in primary tumors and draining lymph nodes is essential for efficient spread of tumor cells through the lymphatic system. Thus, inhibition of lymphangiogenesis could limit lymphatic dissemination of tumor cells. J. Surg. Oncol. 2010;102:809-815. (C) 2010 Wiley-Liss, Inc.