Identification of an inhibitory mechanism of luteolin on the insulin-like growth factor-1 ligand-receptor interaction.
Identification of an inhibitory mechanism of luteolin on the insulin-like growth factor-1 ligand-receptor interaction.
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鉴定木犀草素对胰岛素样生长因子-1 配体-受体相互作用的抑制机制。
DOI：
10.1002/cbic.201300082
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Ferrari,Mauro
中科院分区：
文献类型：
--
作者：
Yang,Yong;Shen,Jianliang;Yu,Xujiang;Qin,Guoting;Zhang,Mingzhen;Shen,Haifa;Mao,Zongwan;Ferrari,Mauro
使用单分子力测量和单分子荧光成像，我们证明了毛地黄黄酮能够对IGF-1配体-受体结合（IGF-1信号传导的初始步骤）产生抑制作用。流式细胞术和分子对接也证实了这种抑制机制。我们的研究证明了毛地黄黄酮作为IGF-1信号抑制剂在癌症治疗中的新分子机制。
Using single-molecule force measurement and single-molecule fluorescence imaging, we demonstrated that luteolin is able to perform an inhibitory effect on IGF-1 ligand-receptor binding, the initial step of IGF-1 signaling. Furthermore, this inhibition mechanism was also confirmed by flow cytometry and molecular docking. Our study demonstrates the novel molecular mechanism of luteolin as an IGF-1 signaling inhibitor in cancer therapy.