Can blocking inflammation enhance immunity during aging?
Can blocking inflammation enhance immunity during aging?
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DOI：
10.1016/j.jaci.2020.03.016
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发表时间：
2020-05-01
影响因子：
14.2
通讯作者：
Akbar, Arne N.
中科院分区：
文献类型：
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作者：
Chambers, Emma S.;Akbar, Arne N.
老龄化是一个全球性的负担，寿命的增加并没有与健康寿命同步增加。因此，老年人目前患有慢性疾病，感染增加和癌症的寿命更长。衰老的一个特征是存在慢性低度炎症，其特征在于IL-6、TNF-α和C-反应蛋白的浓度升高，这被称为炎症。以前的研究已经证明，慢性炎症干扰T细胞反应和巨噬细胞功能，也不利于疫苗反应。这就提出了一个问题，即减少炎症的治疗策略是否有助于提高老年人的免疫力。本文就炎症的潜在原因、炎症介质的细胞来源以及炎症抑制免疫的机制进行综述。最后，我们描述了现有的针对炎症的干预措施，这些干预措施已被用于增强衰老过程中的免疫力。
Aging is a global burden, and the increase in life span does not increase in parallel with health span. Therefore, older adults are currently living longer with chronic diseases, increased infections, and cancer. A characteristic of aging is the presence of chronic low-grade inflammation that is characterized by elevated concentrations of IL-6, TNF-alpha, and C-reactive protein, which has been termed inflammaging. Previous studies have demonstrated that chronic inflammation interferes with T-cell response and macrophage function and is also detrimental for vaccine responses. This raises the question of whether therapeutic strategies that reduce inflammation may be useful for improving immunity in older adults. In this review we discuss the potential causes of inflammaging, the cellular source of the inflammatory mediators, and the mechanisms by which inflammation may inhibit immunity. Finally, we describe existing interventions that target inflammation that have been used to enhance immunity during aging.