Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults
Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults
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DOI：
10.1001/archinternmed.2007.74
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发表时间：
2008-01-25
影响因子：
--
通讯作者：
Guallar, Eliseo
中科院分区：
文献类型：
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作者：
Bleys, Joachim;Navas-Acien, Ana;Guallar, Eliseo
背景：硒是一种参与抗氧化应激的必需微量元素，可预防癌症和心血管疾病。我们评估了硒水平和所有原因和特定原因的死亡率在美国adultes.Methods的代表性样本之间的关联：血清硒水平测定在13 887成人参与者在第三次全国健康与营养检查调查。研究参与者从1988年至1994年招募，并随访死亡率长达12年。结果：平均血清硒水平为125.6 ng/mL。多变量调整的风险比比较最高（>= 130.39 ng/mL），最低（< 117.31 ng/mL）的血清硒水平三分位数分别为0.83（95%置信区间[CI]，0.72-0.96）全因死亡率，0.69（95% CI，0.53-0.90）的癌症死亡率和0.94（95% CI，0.77-1.16）的心血管死亡率。然而，基于样条回归模型，血清硒水平与全因死亡率和癌症死亡率之间的关系是非线性的，在低硒水平（< 130 ng/mL）下呈负相关，在高硒水平（> 150 ng/mL）下死亡率略有增加。血清硒水平和心血管mortals.Conclusions之间没有关联：在美国人口的代表性样本中，我们发现血清硒水平和全因和癌症死亡率之间存在非线性关联。血清硒水平升高与死亡率降低相关，最高可达130 ng/mL。然而，我们的研究引起了人们的关注，即较高的血清硒水平可能与死亡率增加有关。
Background: Selenium, an essential trace element involved in defense against oxidative stress, may prevent cancer and cardiovascular disease. We evaluated the association between selenium levels and all-cause and cause-specific mortality in a representative sample of US adults.Methods: Serum selenium levels were measured in 13 887 adult participants in the Third National Health and Nutrition Examination Survey. Study participants were recruited from 1988 to 1994 and followed up for mortality for up to 12 years.Results: The mean serum selenium level was 125.6 ng/mL. The multivariate adjusted hazard ratios comparing the highest (>= 130.39 ng/mL) with the lowest (< 117.31 ng/mL) serum selenium level tertile were 0.83 (95% confidence interval [CI], 0.72-0.96) for all-cause mortality, 0.69 (95% Cl, 0.53-0.90) for cancer mortality, and 0.94 (95% Cl, 0.77-1.16) for cardiovascular mortality. However, based on spline regression models, the association between serum selenium levels and all-cause and cancer mortality was nonlinear, with an inverse association at low selenium levels (< 130 ng/mL) and a modest increase in mortality at high selenium levels (> 150 ng/mL). There was no association between serum selenium levels and cardiovascular mortality.Conclusions: In a representative sample of the US population, we found a nonlinear association between serum selenium levels and all-cause and cancer mortality. Increasing serum selenium levels were associated with decreased mortality up to 130 ng/mL. Our study, however, raises the concern that higher serum selenium levels may be associated with increased mortality.