Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development.
Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development.
复制标题
卷曲螺旋结构域中的 Brca1 突变阻碍了 Rad51 在 DNA 上的加载和小鼠发育。
DOI：
10.1080/23723556.2020.1786345
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发表时间：
2020
影响因子：
2.1
通讯作者：
Johnson,N
中科院分区：
文献类型：
--
作者：
Krais,JJ;Johnson,N
我们最近建立了Brca1螺旋线圈突变小鼠模型(Brca1CC)。Brca1CC/CC导致胚胎死亡，部分小鼠出生，但存在平行Fanconi贫血的缺陷。Brca1CC/CC细胞缺乏RAD51位点，对PARP抑制剂敏感。令人惊讶的是，与Brca1Δ11杂交产生了发育正常的Brca1CC/Δ11小鼠。
We recently developed aBrca1coiled-coil mutant mouse model (Brca1CC).Brca1CC/CCresults in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia.Brca1CC/CCcells lacked Rad51 foci and were PARP inhibitor sensitive. Strikingly, inter-crossing withBrca1Δ11generatedBrca1CC/Δ11mice that were developmentally normal.