Comparative hypocholesterolemic effects of capybara (Hydrochoerus hydrochaeris dabbenei) oil, horse oil, and sardine oil in cholesterol-fed rats

Comparative hypocholesterolemic effects of capybara (Hydrochoerus hydrochaeris dabbenei) oil, horse oil, and sardine oil in cholesterol-fed rats
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DOI：
10.1007/s11745-997-0050-z
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发表时间：
1997-04-01
期刊：
LIPIDS
影响因子：
1.9
通讯作者：
Nakano, M
Nakano, M
中科院分区：
医学4区
文献类型：
--
作者：
Fukushima, M;Takayama, Y;Nakano, M

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在给予富含胆固醇的饮食的大鼠中比较了各种多不饱和脂肪酸的降胆固醇功效。将水豚油（CO，亚油酸+ α-亚麻酸）、马油（HO，α-亚麻酸）和沙丁鱼油（SO，二十碳五烯酸+二十二碳六烯酸）以50 g/kg添加到饮食中。在为期6周的实验期间，CO喂养组的体重增加、食物摄入量和肝脏重量显著高于其他组。6 wk后，CO组和SO组的血清总胆固醇和极低密度脂蛋白（VLDL）+中密度脂蛋白（IDL）+低密度脂蛋白（LDL）胆固醇浓度均显著低于HO组。SO组血清高密度脂蛋白胆固醇浓度显著高于CO组和HO组。与其他组相比，CO组的粪中性固醇浓度显著降低，HO组的粪胆汁酸浓度显著高于SO组。这项研究的结果表明，CO降低血清总胆固醇和VLDL + IDL + LDL-胆固醇浓度的存在下，过量的胆固醇的饮食以及SO。
The hypocholesterolemic efficacy of various polyunsaturated fatty acids was compared in rats given cholesterol-enriched diets. Capybara oil (CO, linoleic + alpha-linolenic acids), horse oil (HO, alpha-linolenic acid), and sardine oil (SO, eicosapentaenoic + docosahexaenoic acids) were added to diets at 50 g/kg. The weight gain, food intake, and liver weight in the CO-fed group were significantly higher than those in other groups during the 6-wk experimental period. The serum total and very low density lipoprotein (VLDL) + intermediate density lipoprotein (IDL) + low density lipoprotein (LDL) cholesterol concentrations of the CO-fed and SO-fed groups were significantly lower than in the HO-fed group after 6 wk. The serum high density lipoprotein cholesterol concentration in the SO-fed group was significantly higher than that in the CO-fed and HO-fed groups. The fecal neutral sterol concentration in the CO-fed group was reduced significantly compared with the other groups, and the fecal bile acid concentration in the HO-fed group was significantly higher than that in the SO-fed group. The results of this study demonstrate that CO lowers the serum total cholesterol and VLDL + IDL + LDL-cholesterol concentrations in the presence of excess cholesterol in the diet as well as SO.