Association between metal hypersensitivity and implant failure in patients who underwent titanium cranioplasty
Association between metal hypersensitivity and implant failure in patients who underwent titanium cranioplasty
复制标题
接受钛颅骨成形术的患者金属过敏与植入物失败之间的关系
DOI：
10.3171/2018.1.jns171804
复制
发表时间：
2019-07-01
影响因子：
4.1
通讯作者：
Hu, Jin
中科院分区：
文献类型：
--
作者：
Sun, Yirui;Hu, Yue;Hu, Jin
OBJECTIVE Digitally designed titanium plates are commonly used for the reconstruction of craniofacial defects, although implant exposure (referred to as failure) is one of the major complications. Metal hypersensitivities have been suggested as possible causes of implant failure of orthopedic, intravascular, gynecological, and dental devices, yet there has been no consensus on the requirement for allergy screening before cranioplasty.METHODS In this study, the authors prospectively investigated the prevalence of metal hypersensitivity in patients for whom cranioplasty is planned and assess its relationship with titanium implant failure (exposure).RESULTS Based on records from 207 included patients, 39.61% of patients showed hypersensitivity to at least one kind of metal. Approximately one-quarter (25.12%) of patients had multiple metal allergies. Co, Cd, and Zn were the 3 most frequently identified metal hypersensitivities. No allergy to titanium was detected in this study. The overall incidence of cranioplasty implant failure was 5.31% (11 of 207). Patients showing hypersensitivities to more than 3 kinds of metal had higher risks of titanium plate exposure.CONCLUSIONS Based on their findings, the authors suggest that routine allergy screening be performed before titanium plate cranioplasty. For patients with hypersensitivities to more than 3 metals, alternative materials, such as polyetheretherketone, should be considered for cranioplasty.
