Glypican-3 Expression in Patients with Oral Squamous Cell Carcinoma.
Glypican-3 Expression in Patients with Oral Squamous Cell Carcinoma.
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DOI：
10.30476/dentjods.2019.84541.1089
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发表时间：
2020-06-01
期刊：
影响因子：
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通讯作者：
Ranjbar, Mohammad Ali
中科院分区：
文献类型：
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作者：
Andisheh-Tadbir, Azadeh;Goharian, Amir Saeed;Ranjbar, Mohammad Ali
问题说明：口腔鳞状细胞癌（OSCC）是一种影响口腔结构或组织的恶性肿瘤。这些肿瘤的早期诊断对改善治疗结果至关重要。因此，使用基于分子标记的病理技术可能有助于最佳诊断和治疗。磷脂酰肌醇蛋白聚糖-3（GPC-3）参与细胞增殖和形态发生的调控，在胚胎和器官发生过程中含量丰富，但在大多数成体组织中含量有限。GPC3过表达在口腔癌的发生发展中具有重要作用。目的：本研究的目的是探讨GPC3在非肿瘤性口腔上皮和口腔鳞状细胞癌中的表达。材料和方法：在这项横断面研究中，45例OSCC患者（男30例，女15例），平均年龄为52.3岁，选自设拉子牙科学校口腔病理科。对照组为15例正常口腔粘膜。结果：非肿瘤组织中GPC3均为阴性。GPC3在肿瘤组织中的阳性率为73.3%（33例）明显高于非肿瘤组织GPC3的表达与临床病理特征无关，与肿瘤大小无关。GPC3在口腔鳞状细胞癌组织中呈高表达，但其在诊断和治疗中的应用前景尚待进一步研究。
STATEMENT OF THE PROBLEM: Oral squamous cell carcinoma (OSCC) is a malignant neoplasm that affects the structures or tissues of mouth. Early diagnosis of these tumors is important to improve the outcome of treatment. Therefore, using pathological techniques based on molecular markers may be useful for optimal diagnosis and treatment. Glypican-3 (GPC3) is involved in regulation of cell proliferation and morphogenesis and is abundant during embryogenesis and organogenesis but is limited in most of adult tissues. GPC3 overexpression has a role in carcinogenesis.PURPOSE: The aim of the present study was to investigate GPC3 expression in the non-neoplastic oral epithelium and oral squamous cell carcinoma.MATERIALS AND METHOD: In this cross-sectional study, 45 patients with OSCC (30 males and 15 females) with a mean age of 52.3 selected from Oral Pathology Department of Shiraz Dental School were enrolled. The control group was consisted of 15 cases of normal oral epithelium. Glypican-3 expression was assessed by using immunohistochemical methods.RESULTS: Non neoplastic tissues were GPC3 negative. Frequency of GPC3 positivity in tumoral tissues was recorded as 73.3% (33 cases) which was significantly higher than non-neoplastic tissues (p< 0.001).The clinicopathologic features of GPC3 expression demonstrated no association with clinicopathologic parameters except tumor size.CONCLUSION: GPC3 was over expressed at protein level in oral squamous cell carcinoma, but its potential use for diagnostic and therapeutic purposes requires further investigation.