Highly anti-selective asymmetric nitro-mannich reactions catalyzed by bifunctional amine-thiourea-bearing multiple hydrogen-bonding donors.
Highly anti-selective asymmetric nitro-mannich reactions catalyzed by bifunctional amine-thiourea-bearing multiple hydrogen-bonding donors.
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DOI：
10.1021/ja803538x
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发表时间：
2008-06
影响因子：
15
通讯作者：
Chun‐Jiang Wang;Xiuqin Dong;Zhi-Hai Zhang;Zhi-Yong Xue;Huailong Teng
中科院分区：
文献类型：
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作者：
Chun‐Jiang Wang;Xiuqin Dong;Zhi-Hai Zhang;Zhi-Yong Xue;Huailong Teng
手性双官能团多重氢键给体氨基硫脲催化的硝基-曼尼希反应具有高度的反选择性和对映选择性。多个氢键给体在加速反应和提高产率、非对映选择性和对映选择性方面起着重要作用。
Highly anti-selective and enantioselective nitro-Mannich reactions have been achieved for a broad spectrum of substrates catalyzed by chiral bifunctional multiple hydrogen-bonding-donor amine-thioureas. Multiple hydrogen-bonding donors play a significant role in accelerating reactions and improving yields, diastereoselectivities, and enantioselectivities.