Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice
Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice
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DOI：
10.1371/journal.pone.0146886
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发表时间：
2016-01-21
期刊：
影响因子：
3.7
通讯作者：
Obenaus, Andre
中科院分区：
文献类型：
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作者：
Bajwa, Nikita M.;Halavi, Shina;Obenaus, Andre
轻度创伤性脑损伤可导致长期的认知和运动缺陷，增加未来行为，神经和情感障碍的风险。我们的研究集中在重复损伤后的长期行为缺陷，其中小鼠接受单一轻度CHI（mCHI），重复轻度CHI（rmCHI），包括对每个半球的一次撞击，间隔3天，或中度受控皮质撞击损伤（CCI）。Shams只接受了麻醉。在伤后1、3、5、7和90天（dpi）进行行为测试。CCI动物在测试的早期（1-7 dpi）和长期（90 dpi）阶段显示出显著的运动和感觉缺陷。有趣的是，在90 dpi时发现rmCHI动物的感觉和细微运动缺陷。最重要的是，在90 dpi时在rmCHI动物中观察到抑郁样行为和社会被动性。这些数据表明，轻度脑震荡损伤导致运动和感觉缺陷和情感障碍，而中度TBI后没有观察到。
Mild traumatic brain injuries can lead to long-lasting cognitive and motor deficits, increasing the risk of future behavioral, neurological, and affective disorders. Our study focused on long-term behavioral deficits after repeated injury in which mice received either a single mild CHI (mCHI), a repeated mild CHI (rmCHI) consisting of one impact to each hemisphere separated by 3 days, or a moderate controlled cortical impact injury (CCI). Shams received only anesthesia. Behavioral tests were administered at 1, 3, 5, 7, and 90 days post-injury (dpi). CCI animals showed significant motor and sensory deficits in the early (1-7 dpi) and long-term (90 dpi) stages of testing. Interestingly, sensory and subtle motor deficits in rmCHI animals were found at 90 dpi. Most importantly, depression-like behaviors and social passiveness were observed in rmCHI animals at 90 dpi. These data suggest that mild concussive injuries lead to motor and sensory deficits and affective disorders that are not observed after moderate TBI.