Comparative morphology of the whiskers and faces of mice (Mus musculus) and rats (Rattus norvegicus).
Comparative morphology of the whiskers and faces of mice (Mus musculus) and rats (Rattus norvegicus).
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DOI：
10.1242/jeb.245597
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发表时间：
2023-10-01
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影响因子：
--
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中科院分区：
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--
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了解神经功能需要量化动物大脑进化来解释的感觉信号。这些信号反过来又取决于动物感觉结构的形态和机械结构。尽管家鼠(Mus Musculus)是神经科学中最常见的模式物种之一，但其面部传感器的空间排列尚未得到量化。为了解决这一差距，本研究量化了小鼠的面部形态，特别关注其触须(胡须)的几何形状。这项研究建立了在胡须基点的三维(3D)位置、胡须几何形状(弧长、曲率)和胡须从面部露出的3D角度之间建立关系的方程式。此外，面部感觉器官的位置是相对于bregma-lambda进行量化的。与挪威鼠(Rattus Norveicus)的比较表明，当头部大小归一化时，这两个物种的胡须具有相似的间距密度。大鼠面部标志物之间的吻尾距离是∼的2.0倍，而两侧距离的范围更大，变异性更大。我们解释这些数据是为了表明，与老鼠相比，大鼠的体型更大是一种派生的(无形性)特征。由于啮齿动物是行为神经科学中日益重要的模型，这里开发的形态模型将帮助研究人员为神经生理学实验生成自然的、多模式的刺激模式，并允许生成合成数据集和模拟来闭合大脑、身体和环境之间的循环。摘要：小鼠胡须和面部特征的形态模型可以用于行为模拟，并为神经生理学实验产生自然的刺激模式。
Understanding neural function requires quantification of the sensory signals that an animal's brain evolved to interpret. These signals in turn depend on the morphology and mechanics of the animal's sensory structures. Although the house mouse (Mus musculus) is one of the most common model species used in neuroscience, the spatial arrangement of its facial sensors has not yet been quantified. To address this gap, the present study quantifies the facial morphology of the mouse, with a particular focus on the geometry of its vibrissae (whiskers). The study develops equations that establish relationships between the three-dimensional (3D) locations of whisker basepoints, whisker geometry (arclength, curvature) and the 3D angles at which the whiskers emerge from the face. Additionally, the positions of facial sensory organs are quantified relative to bregma-lambda. Comparisons with the Norway rat (Rattus norvegicus) indicate that when normalized for head size, the whiskers of these two species have similar spacing density. The rostral–caudal distances between facial landmarks of the rat are a factor of ∼2.0 greater than the mouse, while the scale of bilateral distances is larger and more variable. We interpret these data to suggest that the larger size of rats compared with mice is a derived (apomorphic) trait. As rodents are increasingly important models in behavioral neuroscience, the morphological model developed here will help researchers generate naturalistic, multimodal patterns of stimulation for neurophysiological experiments and allow the generation of synthetic datasets and simulations to close the loop between brain, body and environment. Summary: A morphological model of the whiskers and facial features of mice can be used in behavioral simulations and to generate naturalistic patterns of stimulation for neurophysiological experiments.
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校正的肌肉校准力精度在啮齿动物的分子树中精确的放置。
影响因子：
4.6
作者：
Kimura Y;Hawkins MT;McDonough MM;Jacobs LL;Flynn LJ
通讯作者：
Flynn LJ
影响因子：
3.7
作者：
Belli, Hayley M.;Bresee, Chris S.;Hartmann, Mitra J. Z.
通讯作者：
Hartmann, Mitra J. Z.
影响因子：
2.5
作者：
Hires, Samuel Andrew;Schuyler, Adam;Golomb, David
通讯作者：
Golomb, David
影响因子：
5.3
作者：
Jin, TE;Witzemann, V;Brecht, M
通讯作者：
Brecht, M
影响因子：
2.9
作者：
Feng, Alice Y. T.;Himsworth, Chelsea G.
通讯作者：
Himsworth, Chelsea G.