Genomic epidemiology of the commercially important pathogen Renibacterium salmoninarum within the Chilean salmon industry.
Genomic epidemiology of the commercially important pathogen Renibacterium salmoninarum within the Chilean salmon industry.
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DOI：
10.1099/mgen.0.000201
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发表时间：
2018-09
影响因子：
3.9
通讯作者：
Feil EJ
中科院分区：
文献类型：
--
作者：
Bayliss SC;Verner-Jeffreys DW;Ryder D;Suarez R;Ramirez R;Romero J;Pascoe B;Sheppard SK;Godoy M;Feil EJ
沙门氏雷氏杆菌是细菌性肾病的病原体，是养殖鲑鱼的一种重要的商业疾病。用常规方法进行分型提供的关于这种病原体进化和传播的信息有限，因为在沙门氏菌种群中存在较低水平的长期变异。在这里，我们对来自智利的42个沙门氏菌分离株进行全基因组测序，主要来自鲑鱼养殖场，以了解BKD在这个国家的流行病学。基因组变异的模式与智利的多次引进相一致，随后在30 年间迅速传播。预计引进日期与智利水产养殖业发展的重大事件大致吻合。我们发现了BKD在智利鲑鱼生产链中传播的显著障碍的证据，这也可以用之前未描述的沙门氏菌寄主嗜性信号来解释。了解BKD的基因组流行病学可以为疾病干预提供信息，并提高经济上重要的三文鱼产业的可持续性。本文包含由MicroReaction托管的数据。
Renibacterium salmoninarum is the causative agent of bacterial kidney disease (BKD), which is a commercially important disease of farmed salmonids. Typing by conventional methods provides limited information on the evolution and spread of this pathogen, as there is a low level of standing variation within the R. salmoninarum population. Here, we apply whole-genome sequencing to 42 R. salmoninarum isolates from Chile, primarily from salmon farms, in order to understand the epidemiology of BKD in this country. The patterns of genomic variation are consistent with multiple introductions to Chile, followed by rapid dissemination over a 30 year period. The estimated dates of introduction broadly coincide with major events in the development of the Chilean aquaculture industry. We find evidence for significant barriers to transmission of BKD in the Chilean salmon production chain that may also be explained by previously undescribed signals of host tropism in R. salmoninarum. Understanding the genomic epidemiology of BKD can inform disease intervention and improve sustainability of the economically important salmon industry. This article contains data hosted by Microreact.
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影响因子：
3.9
作者：
Duchêne S;Holt KE;Weill FX;Le Hello S;Hawkey J;Edwards DJ;Fourment M;Holmes EC
通讯作者：
Holmes EC
影响因子：
3.9
作者：
Barnes AC;Delamare-Deboutteville J;Gudkovs N;Brosnahan C;Morrison R;Carson J
通讯作者：
Carson J
影响因子：
3.9
作者：
Connor TR;Loman NJ;Thompson S;Smith A;Southgate J;Poplawski R;Bull MJ;Richardson E;Ismail M;Thompson SE;Kitchen C;Guest M;Bakke M;Sheppard SK;Pallen MJ
通讯作者：
Pallen MJ
影响因子：
11
作者：
Brynildsrud, Ola;Feil, Edward J.;Verner-Jeffreys, David W.
通讯作者：
Verner-Jeffreys, David W.
影响因子：
3.9
作者：
Page AJ;Taylor B;Delaney AJ;Soares J;Seemann T;Keane JA;Harris SR
通讯作者：
Harris SR