Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission
Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission
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DOI：
10.1016/s0169-328x(99)00333-2
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发表时间：
2000-02-22
期刊：
影响因子：
--
通讯作者：
Ueda, H
中科院分区：
文献类型：
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作者：
Renbäck, K;Inoue, M;Ueda, H
足底（i.pl.）溶血磷脂酸（LPA）注射显著，但当小鼠接受鞘内（i.t.）vzg-1型LPA受体的反义寡脱氧核苷酸治疗。在百日咳毒素治疗条件下观察到的残留LPA伤害性感受（预期为rr，阻滞突触前作用）被苯海拉明（i.pl.）消除。一种H1型组胺受体拮抗剂。考虑到RT-PCR方法在背根神经节中检测到vzg-1 mRNA，这些结果表明，LPA诱导的伤害性感受是通过伤害性感受器末梢上的vzg-1受体，以及通过外周（可能是肥大细胞）上未鉴定的LPA受体来实现的。(C)2000 Elsevier Science B. V.保留所有权利。
The nociception by intraplantar (i.pl.) lysophosphatidic acid (LPA) injection was significantly, but partially blocked when mice received intrathecal (i.t.) antisense oligodeoxynucleotide treatment for the vzg-1 type LPA-receptor. The residual LPA-nociception observed under the condition of pertussis toxin-treatment, which is expected rr, block presynaptic contribution, was abolished by diphenhydramine (i.pl.). an H1-type histamine receptor antagonist. Taking into account that vzg-1 mRNA was detected in the dorsal root ganglion by RT-PCR method, these findings suggest that the LPA-induced nociception is attributed to the mechanism through vzg-1 receptor on nociceptor endings, and to that through unidentified LPA-receptor on peripheral, possibly mast cells. (C) 2000 Elsevier Science B.V. All rights reserved.