Comparison of ThinPrep and conventional smears in salivary gland fine-needle aspiration biopsies
Comparison of ThinPrep and conventional smears in salivary gland fine-needle aspiration biopsies
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DOI：
10.1002/cncr.22575
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发表时间：
2007-04-25
影响因子：
3.4
通讯作者：
Weir, Michele M.
中科院分区：
文献类型：
--
作者：
Parfitt, Jeremy R.;McLachlin, C. Meg;Weir, Michele M.
背景。ThinPrep （TP）细胞学在非血液学标本评估中的应用越来越广泛。很少有研究比较TP和常规涂片在涎腺细针穿刺活检（FNAB）中的应用。本研究比较了SG fnab中TP和CS的诊断准确性和形态学。作者回顾性分析了98例伴TP和CS的满意的SG fnab。所有病例均行手术切除。评估CS和TP切片的多种形态学参数，以及诊断能力。CS与tp比较采用卡方分析。与TP相比，CS的准确诊断更为常见（57%对42%，P= 0.032），而TP的不满意率高于CS（19%对9%，P= 0.041）。TP的错误率（4%）和不确定率（35%）与CS相似。与低细胞性病例相比，细胞性病例的诊断率更高，CS比TP更常见；细胞性TP和细胞性CS的诊断率相似。伪影（挤压、风干、模糊血液）更常见(12%、13%和27%对比2%、0%和1%
BACKGROUND. ThinPrep (TP) cytology for evaluation of nongynecological specimens is being increasingly used. There are few studies comparing TP with conventional smears (CS) in salivary gland (SG) fine-needle aspiration biopsies (FNAB). This study compares diagnostic accuracy and morphology of TP and CS in SG FNABs.METHODS. The authors retrospectively reviewed 98 satisfactory SG FNABs with both TP and CS. All cases had surgical resection. CS and TP slides were assessed for multiple morphological parameters, as well as the ability to make the diagnosis. Chi-square analysis was performed to compare CS and TP.RESULTS. An accurate diagnosis was rendered more commonly with CS compared with TP (57% versus 42%; P=.032), whereas the unsatisfactory rate was greater with TP compared with CS (19% versus 9%; P =.041). The error (4%) and indeterminate (35%) rates for TP were similar to CS. The diagnostic yield was greater for cellular cases, which were more frequent with CS compared with TP, than for cases of low cellularity; the diagnostic yield of cellular TP cases and cellular CS cases was similar. Artifacts (crush, air drying, obscuring blood) were more frequent (12%, 13%, and 27% versus 2%, 0%, and 1%; P