Lung inflation distends small arteries (< 1 mm) in excised dog lungs.
Lung inflation distends small arteries (< 1 mm) in excised dog lungs.
复制标题
肺膨胀使切除的狗肺中的小动脉（< 1 毫米）扩张。
DOI：
10.1152/jappl.1993.75.6.2595
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Dawson,CA
中科院分区：
文献类型：
--
作者：
Albert,RK;Lamm,WJ;Rickaby,DA;al-Tinawi,A;Dawson,CA
我们利用微焦点荧光血管造影术研究了在流动和无流动条件下，肺膨胀对离体犬肺左下叶小（直径0.2- 1.3 mm）肺动脉的影响。肺泡压（在该制备中等于经肺压）设定为2、8或14 mmHg，而血管压在0至24 mmHg之间变化。这些小动脉血管的直径随着肺膨胀而增加。在流动和无流动条件下获得的结果之间未观察到差异。因此，该直径范围内的动脉可被视为肺泡外动脉，肺充气对这些小肺泡外动脉的影响定性类似于先前描述的较大肺泡外血管。定量地说，恒定血管压下每单位的经颅压增加血管扩张的程度与恒定经颅压下血管压变化的程度大致相同。因此，充盈使这些小动脉周围的血管周围压力降低，其大约等于经尿道压力的增加。
We utilized microfocal fluoroscopic angiography to study the influence of lung inflation on small (0.2- to 1.3-mm-diam) pulmonary arteries in isolated left lower lobes from dog lungs during both flow and no-flow conditions. Alveolar pressure, which in this preparation was equal to transpulmonary pressure, was set at 2, 8, or 14 mmHg while vascular pressure was varied from 0 to 24 mmHg. The diameters of these small arterial vessels increased with lung inflation. No differences were observed between the results obtained during flow and no-flow conditions. Thus, arteries in this diameter range can be considered as extra-alveolar, and the effect of lung inflation on these small extra-alveolar arteries was qualitatively similar to that previously described for larger extra-alveolar vessels. Quantitatively, the degree of vessel distension was about the same per unit increase in transpulmonary pressure at constant vascular pressure as for a change in vascular pressure at constant transpulmonary pressure. Accordingly, inflation produced a decrease in perivascular pressure surrounding these small arteries that was approximately equal to the increase in transpulmonary pressure.