Cardiac Biomarkers and Risk of Incident Heart Failure in Chronic Kidney Disease: The CRIC (Chronic Renal Insufficiency Cohort) Study
Cardiac Biomarkers and Risk of Incident Heart Failure in Chronic Kidney Disease: The CRIC (Chronic Renal Insufficiency Cohort) Study
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DOI：
10.1161/jaha.119.012336
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发表时间：
2019-11-05
影响因子：
5.4
通讯作者：
Townsend, Raymond R.
中科院分区：
文献类型：
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作者：
Bansal, Nisha;Zelnick, Leila;Townsend, Raymond R.
背景-心脏生物标志物可能是心力衰竭（HF）的机制途径，心力衰竭是慢性肾脏疾病的主要并发症。我们检测了NT-proBNP（N-末端B型利钠肽前体）、高敏肌钙蛋白T（hsTnT）、半乳糖凝集素-3、生长分化因子-15（GDF-15）和可溶性ST 2（sST 2）与慢性肾脏病HF事件的相关性。在基线时测量所有生物标志物。主要结局为HF事件。次要结局包括射血分数维持（EF >= 50%）和射血分数降低（EF
Background-Cardiac biomarkers may signal mechanistic pathways involved in heart failure (HF), a leading complication in chronic kidney disease. We tested the associations of NT-proBNP (N-terminal pro-B-type natriuretic peptide), high-sensitivity troponin T (hsTnT), galectin-3, growth differentiation factor-15 (GDF-15), and soluble ST2 (sST2) with incident HF in chronic kidney disease.Methods and Results-We examined adults with chronic kidney disease enrolled in a prospective, multicenter study. All biomarkers were measured at baseline. The primary outcome was incident HF. Secondary outcomes included HF with preserved ejection fraction (EF >= 50%) and reduced ejection fraction (EF