Influence of the mannose receptor in host immune responses
Influence of the mannose receptor in host immune responses
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DOI：
10.1016/j.imbio.2008.11.004
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发表时间：
2009-07-01
期刊：
影响因子：
2.8
通讯作者：
Martinez-Pomares, Luisa
中科院分区：
文献类型：
--
作者：
Gazi, Umut;Martinez-Pomares, Luisa
甘露糖受体（MR）是一种C型凝集素，主要由巨噬细胞和树突状细胞表达。它的三个不同的细胞外结合位点识别广泛的内源性和外源性配体，因此MR涉及稳态过程和病原体识别。然而，MR在宿主防御中的功能尚未被清楚地理解，因为MR缺陷动物对携带MR配体的病原体不表现出增强的易感性。当考虑MR在先天免疫激活中的作用时，这种情况甚至更加复杂，因为即使在其胞质尾区没有鉴定出细胞内信号传导基序，MR也已被证明是促炎和抗炎细胞因子产生所必需的。此外，MR可能与其他典型的模式识别受体相互作用，以介导细胞内信号传导。在这篇综述中，我们总结了最近的观察有关MR功能的免疫反应，并集中在其参与吞噬，抗原加工和呈递，细胞迁移和细胞内信号。(C)2008年Elsevier GmbH。All rights reserved.
Mannose receptor (MR) is a C-type lectin primarily expressed by macrophages and dendritic cells. Its three distinct extracellular binding sites recognise a wide range of both endogenous and exogenous ligands, therefore MR has been implicated in both homeostatic processes and pathogen recognition. However, the function of MR in host defence is not yet clearly understood as MR-deficient animals do not display enhanced susceptibility to pathogens bearing MR ligands. This scenario is even more complex when considering the role of MR in innate immune activation as, even though no intracellular signalling motif has been identified at its cytoplasmic tail, MR has been shown to be essential for cytokine production, both pro-inflammatory and anti-inflammatory. Furthermore, MR might interact with other canonical pattern recognition receptors in order to mediate intracellular signalling. In this review, we have summarised recent observations relating to MR function in immune responses and focused on its participation in phagocytosis, antigen processing and presentation, cell migration and intracellular signalling. (C) 2008 Elsevier GmbH. All rights reserved.