15-Deoxyspergualin, an immunosuppressive agent, used in organ transplantation showed suppressive effects on malarial parasites.
15-Deoxyspergualin, an immunosuppressive agent, used in organ transplantation showed suppressive effects on malarial parasites.
复制标题
15-脱氧精胍菌素是一种免疫抑制剂，用于器官移植，对疟疾寄生虫具有抑制作用。
DOI：
10.1159/000239532
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发表时间：
1997
期刊：
影响因子：
3.3
通讯作者：
Q. M. Haque
中科院分区：
文献类型：
--
作者：
Yutaka Midorikawa;Q. M. Haque
脱氧精胍菌素（DSG）是一种免疫抑制剂，本文研究了它对鼠疟寄生虫的体内作用。尽管未用DSG处理的小鼠具有增加的寄生虫百分比（寄生虫血症%）直到它们死亡，但用DSG处理的那些具有降低的寄生虫血症并且最终具有0%寄生虫。DSG治疗后，感染小鼠脾脏变小。停药后，小鼠寄生虫血症再次升高。然而，DSG是多胺抑制剂。本研究中使用的另外两种多胺抑制剂对降低伯氏疟原虫的寄生虫血症%无效。只有DSG可用，小鼠存活时间增加。DSG所显示的抗原虫作用--即使这种化学物质是一种免疫抑制剂--表明DSG的多胺合成途径的抑制或免疫抑制与疟疾寄生虫的抑制作用之间存在关系。
Deoxyspergualin (DSG), which was discovered to be an immunosuppressive agent, was examined for its in vivo effect on parasites of rodent malaria. Although the mice that were not treated by DSG had an increased parasite percentage (% parasitemia) until they died, those that were treated with DSG had a decreased parasitemia and finally had 0% parasites. The spleens of infected mice became small by DSG treatment. Parasitemia of mice increased again after DSG treatment was stopped. However, DSG was a polyamine inhibitor. The two other types of polyamine inhibitors used in this study were not effective for decreasing the % parasitemia of Plasmodium berghei. Only DSG was available and the survival time of mice increased. The antiprotozoal effects shown by DSG-even this chemical is an immunosuppressive agent-suggest that there is a relation between the inhibition of the polyamine synthetic pathway or immunosuppression of DSG and the suppressive effect of malarial parasites.