The Effect of a Multicomponent Dual-Task Exercise on Cortical Thickness in Older Adults with Cognitive Decline: A Randomized Controlled Trial
The Effect of a Multicomponent Dual-Task Exercise on Cortical Thickness in Older Adults with Cognitive Decline: A Randomized Controlled Trial
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DOI：
10.3390/jcm9051312
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发表时间：
2020-05-01
影响因子：
3.9
通讯作者：
Shimada, Hiroyuki
中科院分区：
文献类型：
--
作者：
Bae, Seongryu;Harada, Kenji;Shimada, Hiroyuki
本研究的目的是检查与多成分运动干预相结合的身体锻炼和认知训练的老年人与认知能力下降的皮质厚度的变化。这项研究涉及一项随机对照试验的神经影像学数据的二次分析，其中280名认知功能下降的老年人被随机分配到每周参加90分钟运动和认知训练课程的多成分运动组（n = 140）或健康教育对照组（n = 140）。在基线和试验完成时（10个月）评估皮质厚度和认知能力。使用FreeSurfer软件确定额叶和颞区的皮质厚度。认知性能进行了评估，使用老年学功能评估工具（NCGG-FAT）。与对照组相比，多成分运动组颞中（P < 0.001）和颞极（P < 0.001）皮质厚度显著增加。皮质厚度的变化与10个月的多成分运动干预后的连线测验（TMT）-A、TMT-B和故事记忆的变化显著相关。这项研究表明，结合体育锻炼和认知训练的多成分锻炼计划对大脑健康具有重要意义，特别是在提供保护免受与年龄相关的皮层变薄方面。
The aim of this study was to examine cortical thickness changes associated with a multicomponent exercise intervention combining physical exercise and cognitive training in older adults with cognitive decline. This study involved a secondary analysis of neuroimaging data from a randomized controlled trial with 280 older adults having cognitive decline who were randomly assigned to either a multicomponent exercise group (n = 140) that attended weekly 90-min exercise and cognitive training sessions or a health education control group (n = 140). The cortical thickness and cognitive performance were assessed at the baseline and at trial completion (10 months). The cortical thickness in the frontal and temporal regions was determined using FreeSurfer software. Cognitive performance was evaluated using the Gerontology-Functional Assessment Tool (NCGG-FAT). The cortical thickness significantly increased in the middle temporal (p < 0.001) and temporal pole (p < 0.001) in the multicomponent exercise group compared with the control group. Cortical thickness changes were significantly associated with change in trail making test (TMT)-A, TMT-B, and story memory after a 10-month multicomponent exercise intervention. This study suggests that multicomponent exercise programs combining physical exercise and cognitive training have important implications for brain health, especially in providing protection from age-related cortical thinning.