Thermomechanical behavior of human carotid arteries in the passive state
Thermomechanical behavior of human carotid arteries in the passive state
复制标题
DOI：
10.1152/ajpheart.01099.2004
复制
发表时间：
2005-06-01
影响因子：
4.8
通讯作者：
Hayashi, K
中科院分区：
文献类型：
--
作者：
Guinea, GV;Atienza, JM;Hayashi, K
局部加热或冷却正在扩大用于治疗心血管疾病的临床程序。这些方法的有利实施和发展与更深入地了解动脉对机械和热负荷的反应密不可分。尽管如此，人类血管的基本热力学行为仍然很大程度上是未知的，主要是由于缺乏适当的实验数据。本文通过体外充气实验，研究了温度对人颈动脉被动行为的影响。在0 ~ 200 mmHg范围内，分别在17、27、37、42℃4种不同温度下对11段颈动脉进行了测试。结果表明，温度和应力的联合变化对动脉壁的扩张系数有显著影响，该系数随应力状态由负向正转变，而动脉壁的结构刚度在测试温度范围内没有明显变化。
Localized heating or cooling is expanding the clinical procedures used to treat cardiovascular diseases. Advantageous implementation and development of these methods are linked indissolubly to a deeper understanding of the arterial response to combined mechanical and thermal loads. Despite this, the basic thermomechanical behavior of human blood vessels still remains largely unknown, primarily due to the lack of appropriate experimental data. In this work, the influence of temperature on the passive behavior of human carotid arteries was studied in vitro by means of inflation tests. Eleven carotid segments were tested in the range 0-200 mmHg at four different temperatures of 17, 27, 37, and 42 degrees C. The results show that the combined change of temperature and stress has a dramatic effect on the dilatation coefficient of the arterial wall, which is shifted from negative to positive depending on the stress state, whereas the structural stiffness of the arterial wall does not change appreciably in the range of temperatures tested.