Systemic inflammation (C-reactive protein) in type 2 diabetic patients is associated with ambient air pollution in Pune City, India.
Systemic inflammation (C-reactive protein) in type 2 diabetic patients is associated with ambient air pollution in Pune City, India.
复制标题
DOI：
10.2337/dc12-0388
复制
发表时间：
2013-03
期刊：
影响因子：
16.2
通讯作者：
Yajnik CS
中科院分区：
文献类型：
--
作者：
Khafaie MA;Salvi SS;Ojha A;Khafaie B;Gore SS;Yajnik CS
研究印度浦那1,392例2型糖尿病患者的环境空气污染物与血清C反应蛋白（CRP）浓度之间的关系。进行了一项横断面研究，将2005年3月至2007年5月期间招募的来自Wellcome Trust Genetic（WellGen）研究的2型糖尿病患者的环境空气污染数据（从中央监测点获得）和血浆CRP浓度的每日时间序列联系起来。空气污染对CRP浓度的影响进行了研究，延迟（滞后）0-7天，并在采血前的7天，14天和30天的平均跨度调整年龄，性别，BMI，血红蛋白，空腹血糖，抗炎作用的药物治疗，季节，空气温度和相对湿度。中位CRP浓度为3.49 mg/L。在采血前一天（lag 1），环境空气中SO2和氮氧化物（NOx）浓度增加1 SD，我们观察到CRP显著增加（分别为9.34%和7.77%）。滞后2的影响更高（SO2为12.42%，NOx为11.60%），此后逐渐消失。我们还发现了一个显着的关联与多日平均时间高达30和7天的二氧化硫和氮氧化物，分别。除夏季外，空气动力学轮廓≤10 µm的颗粒物（PM10）与CRP浓度之间无显著相关性。在糖尿病病程较短的患者和未接受他汀类药物和噻唑烷二酮治疗的患者中，这种相关性显著较高。我们首次证明了环境空气污染对印度2型糖尿病患者全身炎症的可能贡献。这可能对糖尿病的血管并发症有影响。
To study the association between ambient air pollutants and serum C-reactive protein (CRP) concentration in 1,392 type 2 diabetic patients in Pune, India. A cross-sectional study was conducted that linked daily time series of ambient air pollution data (obtained from central monitoring sites) and plasma CRP concentration in type 2 diabetic patients from the Wellcome Trust Genetic (WellGen) Study, recruited between March 2005 and May 2007. Air pollution effects on CRP concentration were investigated with delays (lags) of 0–7 days and multiday averaging spans of 7, 14, and 30 days before blood collection adjusted for age, sex, BMI, hemoglobin, fasting plasma glucose, treatment with agents with anti-inflammatory action, season, air temperature, and relative humidity. Median CRP concentration was 3.49 mg/L. For 1 SD increase in SO2 and oxides of nitrogen (NOx) concentrations in ambient air, a day before blood collection (lag1), we observed a significant increase in CRP (9.34 and 7.77%, respectively). The effect was higher with lag2 (12.42% for SO2 and 11.60% for NOx) and wore off progressively thereafter. We also found a significant association with multiday averaging times of up to 30 and 7 days for SO2 and NOx, respectively. No significant associations were found between particulate matter with an aerodynamic profile ≤10 µm (PM10) and CRP concentration except in summer. The association was significantly higher among patients with a shorter duration of diabetes, and in those not on statin and thiazolidinedione treatment. We demonstrate, for the first time, a possible contribution of ambient air pollution to systemic inflammation in Indian type 2 diabetic patients. This may have implications for vascular complications of diabetes.