Retinoic acid and polyriboinosinic acid act synergistically to enhance the antibody response to tetanus toxoid during vitamin A deficiency:: Possible involvement of interleukin-2 receptor-β, signal transducer and activator of transcription-1, and interferon regulatory factor-1
Retinoic acid and polyriboinosinic acid act synergistically to enhance the antibody response to tetanus toxoid during vitamin A deficiency:: Possible involvement of interleukin-2 receptor-β, signal transducer and activator of transcription-1, and interferon regulatory factor-1
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DOI：
10.1086/315908
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发表时间：
2000-09-01
影响因子：
6.4
通讯作者：
Ross, AC
中科院分区：
文献类型：
--
作者：
DeCicco, KL;Zolfaghari, R;Ross, AC
对T细胞依赖性抗原的抗体应答在维生素A（VA）缺乏期间减少，并通过类维生素A恢复。为了测试是否维甲酸（RA）和聚肌苷酸：聚胞苷酸（PIC），干扰素的诱导剂，可以增加特异性抗体的产生，VA缺陷的大鼠进行了治疗与全反式RA，猪，或在初级免疫破伤风环的时间。VA缺乏大鼠产生低的初次和二次抗破伤风IgG应答（P
Antibody responses to T cell-dependent antigens are reduced during vitamin A (VA) deficiency and restored by retinoids. To test whether retinoic acid (RA) and polyinosinic:polycytidylic acid (PIC), an inducer of interferons, can increase specific antibody production, VA-deficient rats were treated with all-trans-RA, PIG, or both at the time of primary immunization with tetanus toroid. VA-deficient rats produced low primary and secondary antitetanus IgG responses (P