Fatty acid amides and anilides, syntheses and antimicrobial properties
Fatty acid amides and anilides, syntheses and antimicrobial properties
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脂肪酸酰胺和苯胺、合成和抗菌特性
DOI：
10.1007/bf02674376
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
W. Linfield
中科院分区：
文献类型：
--
作者：
R. G. Bistline jrJr.;E. W. Maurer;F. Smith;W. Linfield
A series of fatty acid amides anilides was prepared and a number of compounds in the series were found to be highly active against gram positive bacteria but ineffective against gram negative organisms. The N,N‐dimethyl‐ and N,N‐diethylamides of C12‐C14fatty acids had minimal inhibitory concentration (MIC) values of 100 ppm or less. Substituted anilides of C6‐C11fatty acids were active when the following groups were attached to the aromatic ring: 3,4‐dichloro, 3‐nitro, 4‐nitro, 5‐chloro‐2‐hydroxy, 4‐chloro‐3‐nitro, and 2‐hydroxy‐5‐nitro. Some of these compounds had a MIC value of 0.1 ppm. Significantly, the presence of soap did not reduce the activity of these bacteriostats, whereas polysorbate 80 at high concentrations deactivated the compounds.
